Chuanxiongzine relaxes isolated corpus cavernosum strips and raises intracavernous pressure in rabbits.

International Journal of Impotence Research
H-J XiaoX Gao

Abstract

It has been shown that there are many Chinese traditional herbals that can enhance sexual activity. Chuanxiongzine is a vasoactive ingredient that has been isolated and purified from Ligusticum chuanxiong Hort. In previous studies, it has been found that chuanxiongzine was effective in relaxing rabbit corpus cavernosum smooth muscle. We determined the effects of chuanxiongzine on relaxation of isolated corpus cavernosum strips in vitro and on increase of intracavernous pressure (ICP) in vivo in rabbits. Chuanxiongzine caused a concentration-dependent relaxation of phenylephrine precontracted isolated corpus cavernosum strips (EC(50) 1.58 x 10(-4) mol l(-1)), which were endothelium independent and NO independent. However, the guanylyl cyclase inhibitor 1-H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one significantly shifted the chuanxiongzine concentration-response relationship to the right. Although there was no significant difference in the level of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) in isolated corpus cavernosum strips treated with chuanxiongzine or vehicle, chuanxiongzine caused a significant rise in the level of cGMP and cAMP in isolated corpus cavernosum strips pretreated with the ...Continue Reading

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Citations

Jan 18, 2018·Chinese Journal of Integrative Medicine·Rui TanHo Sub Lee
Jan 9, 2019·Environmental Science and Pollution Research International·Kaixuan ZhangXiangyu Xu
May 18, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Joseph C MullerThomas Z Hayward
Oct 22, 2011·Pharmaceutical Biology·Xia RanLu-Ping Qin

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