PMID: 8199173Jun 1, 1994Paper

Chylomicron-induced prothrombin activation and platelet aggregation

Arteriosclerosis and Thrombosis : a Journal of Vascular Biology
N XuA Nilsson

Abstract

The effects on platelet aggregation of native rat chyle chylomicrons, chylomicron remnants, and chylomicrons that had been preincubated with rat or human EDTA-plasma, serum, whole blood, or pure human prothrombin were examined. The native chyle chylomicrons did not induce platelet aggregation but decreased ADP- and thrombin-induced platelet aggregation and [14C]serotonin release. Chylomicron remnants also failed to induce platelet aggregation, but they potentiated the aggregation and the [14C]serotonin release induced by ADP and thrombin. Aggregation, after a lag phase of 15 to 20 minutes, was seen when platelets were incubated with chylomicrons that had been preincubated with plasma and then isolated as the top layer after a single centrifugation at d = 1.006. This aggregation was inhibited in a dose-dependent manner by an antiserum against prothrombin that also inhibited thrombin-induced platelet aggregation. After washing by centrifugation the plasma-preincubated chylomicrons did not induce platelet aggregation, but this effect could be restored by adding a small amount of prothrombin, which did not cause aggregation when added alone or together with native chyle chylomicrons. Addition of 2% (vol/vol) plasma, however, induce...Continue Reading

References

Sep 1, 1979·Circulation·D B Zilversmit
Mar 1, 1976·Metabolism: Clinical and Experimental·J D BrunzellE L Bierman
Jul 1, 1988·Seminars in Thrombosis and Hemostasis·W A Bradley, S H Gianturco
Jul 1, 1988·Seminars in Thrombosis and Hemostasis·J G Brook, M Aviram
Jan 1, 1986·Annals of the New York Academy of Sciences·W A BradleyS H Gianturco
Oct 16, 1986·The New England Journal of Medicine·D J FitzgeraldG A FitzGerald
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Jul 1, 1970·British Journal of Haematology·N G ArdlieJ F Mustard
Dec 31, 1982·Biochemical and Biophysical Research Communications·W A BradleyS H Gianturco
Mar 1, 1983·Atherosclerosis·M Aviram, J G Brook
Sep 1, 1981·The American Journal of Medicine·B B Weksler, R L Nachman
Mar 1, 1982·The Medical Clinics of North America·J D Brunzell, E L Bierman
Nov 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K LippelG Vahouny
Jan 1, 1993·Progress in Lipid Research·G J Miller

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Citations

Jan 15, 1996·Thrombosis Research·N XuA Nilsson
Aug 10, 1999·Critical Reviews in Oncology/hematology·L L Horstman, Y S Ahn
Apr 3, 1997·The New England Journal of Medicine·J Pedro-Botet, J Rubíes-Prat
Jul 9, 2013·Journal of Atherosclerosis and Thrombosis·Hiroyasu YamamotoShijin Kihara
Jan 16, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N XuA Nilsson

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