PMID: 16505590Mar 1, 2006Paper

Chylomicron remnants stimulate release of interleukin-1beta by THP-1 cells

Journal of Atherosclerosis and Thrombosis
Takahiro OkumuraMitsumasa Ohyanagi

Abstract

Recent findings suggest that the oxidative modification of low-density lipoproteins (LDL) and an increase in triglyceride-rich lipoprotein particles including chylomicron remnants contribute to the progression of atherosclerosis, as does the inflammatory response. We therefore examined whether and how these lipoproteins affected interleukin (IL)-1beta release and mRNA expression for IL-1beta and IL-18 in THP-1 cells, a human monocyte cell line. Chylomicron remnants increased IL-1beta release into the conditioned medium by THP-1 in a dose- and time-dependent manner. At concentrations up to 1 microg/ml, chylomicron remnants increased IL-1beta release by 4-fold compared with the control. Neither native LDL nor oxidized LDL (OxLDL) significantly increased IL-1beta release. Chylomicron remnants increased IL-1beta mRNA expression by 3 times. Native LDL or OxLDL did not increase IL-1beta mRNA, while neither these lipoproteins nor chylomicron remnants increased IL-18 mRNA. Chylomicron remnants also increased the activities of caspase-1 and nuclear factor (NF)-kappaB significantly, while native LDL or OxLDL did not. In conclusion, chylomicron remnants stimulated IL-1beta mRNA expression and IL-1beta protein production probably via caspa...Continue Reading

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Citations

Feb 5, 2008·Current Atherosclerosis Reports·Tamio Teramoto
May 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Mihai G Netea, Charles A Dinarello
Sep 11, 2012·Journal of Clinical Biochemistry and Nutrition·Chitaka TakahashiYorihiro Yamamoto
Jun 27, 2009·Journal of Atherosclerosis and Thrombosis·Yoshio Fujioka, Yuichi Ishikawa
Aug 3, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C BentleyC Lawson
Nov 11, 2016·Journal of Atherosclerosis and Thrombosis·Daisaku Masuda, Shizuya Yamashita
Nov 28, 2012·The Journal of Allergy and Clinical Immunology·Jianing LiErik R M Eckhardt

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