Chymase inhibitors may prevent postoperative adhesion formation

Fertility and Sterility
Yukiko OkamotoMizuo Miyazaki

Abstract

To clarify the role of chymase produced from mast cells in adhesion formation, we measured chymase activity level and investigated the preventive effect of a chymase inhibitor, Suc-Val-Pro-Phe(p)(OPh)(2), on the postoperative adhesion formation. Prospective randomized study using a surgical model for adhesion formation. Clean hamsters in an academic research environment. Sixty-seven female Syrian hamsters. Hamsters were given a lesion, produced by uterus scraping, and the chymase inhibitor (10 microM) or placebo was injected into the abdomen. Chymase activities in uteri were measured 3 days after the operation, and the scores of adhesion formations were assessed at 2 weeks. Measurement of chymase activity and scoring of adhesion formation were performed. A significant increase of chymase activity in the injured uterus reduced by treatment with the chymase inhibitor. The scores of adhesion formations in the chymase inhibitor-treated group were significantly decreased in comparison with those in the placebo-treated group. Chymase contained in mast cells plays an important role in adhesion formation, and a chymase inhibitor may be a useful drug for prevention of adhesion formation.

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Citations

Mar 6, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Michiko MuramatsuMizuo Miyazaki
Jul 31, 2007·Journal of Cardiac Surgery·Yoshiharu SogaMasashi Komeda
Oct 7, 2004·European Journal of Pharmacology·Shinji TakaiMizuo Miyazaki
Dec 25, 2019·Physiological Reports·Benjamin J BivonaLisa M Harrison-Bernard
Apr 3, 2020·Surgery Today·Shuangping LiuShinji Takai

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