Ci-hox12 tail gradient precedes and participates in the control of the apoptotic-dependent tail regression during Ciona larva metamorphosis

Developmental Biology
G KrasovecJean-Philippe Chambon

Abstract

At the onset of the Ciona intestinalis metamorphosis, the first event is tail regression characterized, by a contraction, an apoptotic wave and Primordial Germ Cells (PGC) movement. All these cell behaviors originate from the posterior tail tip and progress to the anterior. Interestingly, earlier in Ciona development, the antero-posterior (A/P) patterning of the tailbud epidermis depends on two antagonist gradients, respectively FGF/MAPK at the posterior and retinoic acid (RA) at the anterior part of the tail. Fundamental genes such as Ci-hox1, Ci-hox12 and Ci-wnt5, classically involved in chordates A/P polarity and patterning, are controlled by these gradients and exhibit specific expression profiles in the tail epidermis. In this study, we first confirmed by video-microscopy that tail regression depends on a postero-anterior wave of a caspase-dependent apoptosis coupled with a contraction event. Concomitantly an apoptotic-dependent postero-anterior movement of PGC was observed for the first time. Unexpectedly, we observed that expression of the posterior hox gene, Ci-hox12, was extended from a posterior localization to the entire tail epidermis as the larvae progress from the swimming period to the settlement stage. In additi...Continue Reading

References

Oct 26, 2000·Nature·P MeierG Evan
Dec 29, 2000·International Review of Cytology·C R Altmann, A H Brivanlou
Mar 5, 2002·Development Genes and Evolution·Katsumi TakamuraYasunori Yamaguchi
Feb 1, 1965·Journal of Insect Physiology·R A LOCKSHIN, C M WILLIAMS
May 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Raffaella Tarallo, Paolo Sordino
Oct 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tetsuro IkutaHidetoshi Saiga
Apr 14, 2005·Biology of the Cell·Mylène WeillPhilippe Fort
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·N TakadaH-G Wang
Dec 8, 2006·Developmental Biology·Ai-Sun TsengMichael Levin
Jan 2, 2007·Seminars in Cancer Biology·Stephen BaghdiguianPaul Mangeat
Mar 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David R GudeSarah Spiegel
Jul 30, 2008·Methods in Enzymology·Alena Vaculova, Boris Zhivotovsky
Sep 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stefanie D Hueber, Ingrid Lohmann
Sep 20, 2008·Science·Yusuke ToyamaGlenn S Edwards
Dec 23, 2008·Developmental Biology·Akie Nakayama-IshimuraYasunori Sasakura
Feb 13, 2010·Cold Spring Harbor Protocols·Lionel ChristiaenMichael Levine
May 4, 2010·Developmental Biology·Moises MalloJacqueline Deschamps
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shizue OhsawaMasayuki Miura
Dec 18, 2012·Cellular and Molecular Life Sciences : CMLS·Yoshifumi Yamaguchi, Masayuki Miura
Mar 2, 2013·Cell Death and Differentiation·M Suzanne, H Steller
Sep 25, 2014·Genesis : the Journal of Genetics and Development·Anthi KaraiskouJean-Philippe Chambon
Jan 22, 2015·Nature·Bruno MonierMagali Suzanne
Apr 19, 2015·Developmental Biology·Narudo KawaiYasunori Sasakura
Jun 24, 2015·Developmental Biology·Shohei Matsunobu, Yasunori Sasakura
Oct 4, 2015·Current Topics in Developmental Biology·Katrin DomschIngrid Lohmann
Dec 7, 2016·Biochemical and Biophysical Research Communications·Katharina KlöditzBengt Fadeel

❮ Previous
Next ❯

Citations

Apr 29, 2021·Médecine sciences : M/S·Aurore VullienEve Gazave
May 27, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gabriel KrasovecJean-Philippe Chambon
Apr 22, 2021·Integrative and Comparative Biology·Alexander C A FodorBillie J Swalla
Oct 8, 2021·BMC Molecular and Cell Biology·Gabriel KrasovecJean-Philippe Chambon
Nov 16, 2021·Frontiers in Cell and Developmental Biology·Ildiko M L SomorjaiJordi Garcia-Fernàndez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.