Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1.

The Journal of Biological Chemistry
R W JohnstoneY Shi

Abstract

The Wilms tumor suppressor protein, WT1, is a transcription factor capable of activating or repressing transcription of various cellular genes. The mechanisms involved in regulating the transcriptional activities of WT1 are beginning to be unraveled. It appears that physical interactions of other cellular proteins (p53 and par-4) with WT1 can modulate the function of WT1. Here, we report the identification and cloning of a novel WT1-interacting protein termed Ciao 1, a member of the WD40 family of proteins. Ciao 1 specifically interacts with WT1 both in vitro and in vivo. This interaction alters the mobility of a WT1.DNA complex in gel shift assays, and results in a decrease in transcriptional activation mediated by WT1. Ciao 1 does not inhibit binding of WT1 to its consensus nucleotide sequence and does not affect the repression activity of WT1. Thus, Ciao 1 appears to specifically modulate the transactivation activity of WT1 and may function to regulate the physiological functions of WT1 in cell growth and differentiation.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1992·Advances in Cancer Research·D A Haber, D E Housman
Apr 1, 1992·Genomics·M GesslerG A Bruns
Jul 28, 1992·FEBS Letters·L van der Voorn, H L Ploegh
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D A HaberD E Housman
Feb 21, 1992·Cell·C A KeleherA D Johnson
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·P MoffettJ Pelletier
Sep 1, 1995·Genes & Development·S MaheswaranD A Haber
May 5, 1995·The Journal of Biological Chemistry·J C ReddyJ D Licht
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·T KudohT Akiyama
Jun 1, 1994·Molecular and Cellular Biology·I A DrummondV P Sukhatme
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D RonD Mochly-Rosen
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·H KosekiA Gossler
Jan 1, 1993·Mechanisms of Development·J F ArmstrongJ B Bard
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MaheswaranD A Haber
Jul 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M J CoppesB R Williams
Aug 27, 1993·Cell·J A KreidbergR Jaenisch
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·N TaneseA Admon
Jul 1, 1997·Molecular and Cellular Biology·S F SellsV M Rangnekar
Oct 7, 1997·Molecular and Cellular Biology·K Komachi, A D Johnson

❮ Previous
Next ❯

Citations

May 20, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M LittleP Walsh
May 25, 2001·International Journal of Hematology·H Sugiyama
Jun 25, 2013·Journal of Biomolecular NMR·Bingjie OuyangBin Xia
May 24, 2005·Experimental Cell Research·Emelie SvenssonUrban Gullberg
Aug 2, 2002·Biochimica Et Biophysica Acta·Xiaojuan DuRoland Schüle
Oct 12, 2001·Gene·V ScharnhorstA G Jochemsen
Aug 20, 2005·Nature Reviews. Cancer·Miguel N Rivera, Daniel A Haber
Jul 25, 2000·BJU International·K J Turner
Aug 31, 2002·Journal of Hematotherapy & Stem Cell Research·Elizabeth Algar
Sep 26, 2000·Human Molecular Genetics·N A LittleR C Davies
Aug 24, 1999·Current Opinion in Nephrology and Hypertension·H T Cohen
Dec 21, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A BaranovaA Christensen
Jun 25, 2008·Molecular and Cellular Biology·Oliver StehlingRoland Lill
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Roland Lill, Ulrich Mühlenhoff
Dec 4, 2008·Future Lipidology·Erhard Bieberich
Aug 25, 2007·Journal of Molecular Biology·Raphael StollPeter E Wright
Mar 10, 2001·Experimental Cell Research·S B Lee, D A Haber
Jun 29, 2004·Biochemical and Biophysical Research Communications·Brett A ChromySandra L McCutchen-Maloney
Feb 20, 2004·Hematology·Tsutomu Shichishima, Hideyoshi Noji
May 2, 2014·Frontiers in Endocrinology·Anders RehfeldLennart Friis-Hansen
Feb 18, 2004·Physiological Genomics·Maria Teresa Discenza, Jerry Pelletier
Nov 11, 2006·Circulation Research·Theodore W SmallJ Geoffrey Pickering
Mar 16, 2007·Leukemia·L YangM D Minden
Apr 1, 2000·The Journal of Biological Chemistry·V ScharnhorstA G Jochemsen
Jan 23, 2004·The Journal of Biological Chemistry·Manakan B SrichaiJohn R Sedor
Jun 14, 2014·The Biochemical Journal·Eneda Toska, Stefan G E Roberts
Mar 19, 2019·Frontiers in Genetics·George S KrasnovAlexey A Dmitriev
May 15, 2020·Cell Death & Disease·Jean JungKwang-Wook Choi
Jul 30, 2021·Clinical and Translational Medicine·Shao-Yu ZhangCarole Henique

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.