PMID: 11916132Mar 28, 2002Paper

Cicatricial pemphigoid differs from bullous pemphigoid and pemphigoid gestationis regarding the fine specificity of autoantibodies to the BP180 NC16A domain

Journal of Dermatological Science
Arno KrommingaD Zillikens

Abstract

Bullous pemphigoid (BP), pemphigoid (herpes) gestationis (PG), cicatricial pemphigoid (CP), and lichen planus pemphigoides (LPP) are autoimmune subepidermal bullous diseases that are characterized by circulating autoantibodies to the transmembrane hemidesmosomal protein BP180/type XVII collagen. Previous studies demonstrated that the majority of patients with BP, PG, and LPP show antibodies to an immunodominant, membrane-proximal non-collagenous domain (NC16A) on the extracellular portion of BP180. By the use of non-overlapping peptides of the NC16A domain, we previously demonstrated that autoantibodies from BP and PG patients mainly react with epitopes clustered within the N-terminus of this immunodominant site of BP180; antibodies from patients with LPP also recognized the C-terminal portion of NC16A. However, some of these results had been obtained indirectly by preadsorption studies. The aim of the present study was to analyze the fine specificity of IgG autoantibodies to NC16A in sera from patients with CP and to compare their reactivity with antibodies from BP, PG, and LPP patients using a series of new overlapping fragments covering the entire NC16A domain. We confirm that BP and PG sera mainly react with N-terminal epit...Continue Reading

References

Jan 1, 1981·Bioscience Reports·F Sanger
Dec 11, 1981·Science·F Sanger
Nov 15, 1993·The Journal of Immunology : Official Journal of the American Association of Immunologists·G J GiudiceL A Diaz
Jun 24, 1999·Journal of Dermatological Science·D Zillikens
Sep 10, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M S LinG J Giudice

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Citations

Sep 25, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Iakov ShimanovichDetlef Zillikens
Apr 9, 2005·The Journal of Investigative Dermatology·Vassiliki BekouMichael Hertl
Feb 14, 2004·The Journal of Investigative Dermatology·Giovanni Di ZenzoGiovanna Zambruno
Jun 30, 2005·Oral Diseases·J BaganC Scully
Oct 21, 2006·Journal of the American Academy of Dermatology·Luis A CastroLawrence E Gibson
Dec 1, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·H IrieK Kabashima
Jul 18, 2019·Frontiers in Immunology·Franziska HübnerAndreas Recke
Nov 29, 2011·Dental Clinics of North America·Michael H Chan, Joshua C Wolf

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