Ciclesonide versus placebo for chronic asthma in adults and children.

The Cochrane Database of Systematic Reviews
P ManningT J Lasserson

Abstract

Inhaled corticosteroids are an integral part of asthma management, and act as an anti-inflammatory agent in the airways of the lung. These agents confer significant benefit in terms of symptom management and improvement in lung function, but may also cause harm in terms of local and systemic side-effects. Ciclesonide is a novel steroid that has efficient distribution and release properties that mean it can be taken once daily, making it potentially useful in ongoing asthma management. To assess the efficacy of inhaled ciclesonide in adults and children with chronic asthma. We searched the Cochrane Airways Group register of trials with pre-defined terms. Additional searches of CENTRAL and PubMed were undertaken. The literature searches for this review are current up to June 2007. Randomised parallel or crossover studies were eligible for the review. We included studies comparing ciclesonide with placebo, and we also included studies comparing ciclesonide at different doses. Two authors assessed studies for inclusion in the review, extracted data independently and checked each others' work. We contacted study investigators in order to obtain additional data. Extracted data were entered into RevMan 4.2 and analysed as fixed effect...Continue Reading

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Citations

Jan 1, 2010·Journal of Asthma and Allergy·Neal Shahidi, J Mark Fitzgerald
Nov 26, 2015·The Cochrane Database of Systematic Reviews·Bhupendrasinh F ChauhanFrancine M Ducharme
Sep 17, 2013·Cell Biology and Toxicology·Timothy C Marrs, R L Maynard
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Jun 20, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Simon G RoyceChrishan S Samuel
Apr 16, 2010·The Cochrane Database of Systematic Reviews·Francine M DucharmeToby J Lasserson

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