PMID: 2494897Jan 1, 1989Paper

Cidex-induced synovitis

The American Journal of Sports Medicine
C D HarnerB S Rabin

Abstract

Microscopic evidence of inflammation was observed in the synovium of rabbit knees that had been injected with 10 ppm of Cidex (2% glutaraldehyde). Initial changes were synovial hypertrophy, subsynovial edema, and vascular congestion. At concentrations of 100 ppm or greater, focal synovial necrosis, hemorrhage, and gross diffuse synovitis were observed. The degree of synovial inflammation was proportional to the concentration of Cidex. Observation of synovial response versus time demonstrated this reaction to be a chemical synovitis without histologic evidence of a delayed hypersensitivity allergic component. Significant intraoperative levels of Cidex were noted in the rise solutions at several hospitals. When a single rinse is used, the concentration of Cidex present in the rinse basin is 100 to 300 ppm. If the same rinse is used for subsequent cases, the Cidex concentration is on the order of 1,000 ppm by the fifth arthroscopic procedure. If a double rinse is used and the rinse changed with each operative case, the Cidex concentration in the second rinse is less than 10 ppm. After irrigation of the knee joint with 1 liter of saline, the intraarticular concentration of Cidex is less than 10 ppm regardless of the rinse technique.

References

Jul 1, 1967·Anesthesia and Analgesia·D H HaselhuhnP M Borick
Apr 1, 1967·The Journal of Applied Bacteriology·S D RubboR L Webb
Oct 1, 1964·Journal of Pharmaceutical Sciences·P M BORICKV L CHANDLER
Jan 1, 1965·Annals of Surgery·M S RITTENBURY, M E HENCH

❮ Previous
Next ❯

Citations

Jul 9, 1999·Journal of Biomedical Materials Research·J A Schroeder, M K Brown
Feb 22, 2003·Surgical Infections·J L Sagripanti, A Bonifacino
Mar 5, 2004·Journal of Shoulder and Elbow Surgery·Scott D MairRichard J Hawkins
Sep 3, 2004·Clinical Biomechanics·Joanne E LabriolaRichard E Debski
Dec 14, 2004·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Andrew GreenDaniel Labrador
Apr 26, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Adnan HutHuseyin Kilincaslan
Jan 11, 1992·Critical Reviews in Toxicology·R O BeauchampF W Kari
Nov 1, 2003·The Journal of International Medical Research·N TosunA Dogan
Apr 1, 1996·Clinical Orthopaedics and Related Research·M R Safran, C D Harner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
M Mohr, H R Henche
© 2022 Meta ULC. All rights reserved