Cidofovir in combination with HAART and survival in AIDS-associated progressive multifocal leukoencephalopathy.

Journal of Neurology
Christoffer KraemerIngo W Husstedt

Abstract

Progressive multifocal leukoencephalopathy is a demyelinating disease with a high mortality caused by the JC virus and occurs in about 5% of HIV-infected patients. Highly active anti-retroviral therapy (HAART) has a proven efficacy in prolonging the survival of patients with AIDS-associated PML, but there are differing opinions about adding cidofovir to the treatment of PML. To investigate the benefit of HAART combined with cidofovir, we retrospectively analysed the survival of 33 patients with AIDS-associated PML proven by PCR in CSF, biopsy or at autopsy. Additionally, we also analysed 37 patients with probable PML. Seventeen (51.5%) of the patients with confirmed PML were treated with HAART and 14 (42.4%) with cidofovir in any combination. Of these patients, 13 (39.4%) were treated with HAART and cidofovir in combination, four (12.1%) patients received only HAART without cidofovir and one (3%) patient received only cidofovir without HAART. Fifteen patients did not receive HAART or cidofovir. The cumulative survival was significantly longer in patients with HAART than in patients without HAART (p = 0.006), independent whether cidofovir was given or not. In comparison with single therapy with HAART, the combination of HAART an...Continue Reading

References

Mar 1, 1997·Antimicrobial Agents and Chemotherapy·G AndreiE De Clercq
Jul 17, 1999·Medizinische Klinik·J C WasmuthJ K Rockstroh
Nov 30, 2000·Current Treatment Options in Neurology·J R Berger
Jun 21, 2001·The Annals of Pharmacotherapy·M Segarra-Newnham, K M Vodolo
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel J Skiest
Sep 10, 2002·AIDS·Christina M MarraUNKNOWN Adult AIDS Clinical Trials Group 363 Team
Apr 4, 2003·International Journal of Antimicrobial Agents·M T M RobertsA M L Lever
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan BerenguerUNKNOWN GESIDA 11/99 Study Group
May 6, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Erik De Clercq
May 29, 2004·Current Opinion in Neurology·Igor J Koralnik
Sep 24, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christoph WyenGerd Fätkenheuer
Aug 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·R ReilmannI W Husstedt

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Citations

Mar 30, 2010·Der Nervenarzt·T Weber, W Köhler
Jan 27, 2012·Rinshō shinkeigaku = Clinical neurology·Hidehiro MizusawaMasahito Yamada
Feb 1, 2014·Journal of Neurovirology·Kari WiedingerSulie Chang
Sep 20, 2011·Best Practice & Research. Clinical Haematology·Shigeo FujiHermann Einsele
Sep 22, 2011·Reviews in Medical Virology·Eleonora TavazziKamel Khalili
Jan 31, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H H HirschA Wieszek
Jun 6, 2013·Clinical & Developmental Immunology·Cillian F De Gascun, Michael J Carr
Feb 5, 2009·Expert Opinion on Pharmacotherapy·Beatriz HernándezSantiago Moreno
Mar 18, 2021·Reviews in Medical Virology·Zongsong WuHans H Hirsch

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