Cigarette Smoke and E-Cigarette Vapor Dysregulate Osteoblast Interaction With Titanium Dental Implant Surface

The Journal of Oral Implantology
Mahmoud RouabhiaReginaldo Bruno Gonçalves

Abstract

The purpose of this study was to determine the possible deleterious effects of e-cigarette vapor on osteoblast interaction with dental implant material. Osteoblasts were cultured onto Ti6Al4V titanium implant disks and were then exposed or not to whole cigarette smoke (CS), as well as to nicotine-rich (NR) or nicotine-free (NF) e-vapor for 15 or 30 minutes once a day for 1, 2, or 3 days, after which time various analyses were performed. Osteoblast growth on the titanium implant disks was found to be significantly ( P < .001) reduced following exposure to CS and to the NR and NF e-vapors. Osteoblast attachment to the dental implant material was also dysregulated by CS and the NR and NF e-vapors through a decreased production of adhesion proteins such as F-actin. The effects of CS and e-cigarette vapor on osteoblast growth and attachment were confirmed by reduced alkaline phosphatase (ALP) activity and tissue mineralization. The adverse effects of CS and the NR and NF e-vapors on osteoblast interaction with dental implant material also involved the caspase-3 pathway, as the caspase-3 protein level increased following exposure of the osteoblasts to CS or e-vapor. It should be noted that the adverse effects of CS on osteoblast grow...Continue Reading

References

Apr 1, 1984·Clinical Pharmacology and Therapeutics·N L Benowitz, P Jacob
Dec 1, 1996·The Journal of Prosthetic Dentistry·R HaasG Watzek
May 18, 1999·Journal of Periodontology·B H MullallyG J Linden
Aug 31, 2002·Journal of Periodontal Research·Yu-Chao ChangMing-Yung Chou
Dec 20, 2005·Implant Dentistry·Liran Levin, Devorah Schwartz-Arad
Mar 24, 2006·Journal of Clinical Periodontology·Ann-Marie Roos-JansåkerStefan Renvert
Feb 6, 2007·Journal of Periodontology·Arturo Sánchez-PérezR G Caffesse
Apr 22, 2008·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·J A AndrewsM F Barckley
Sep 9, 2008·Journal of Clinical Periodontology·Lisa J A Heitz-Mayfield
Feb 10, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yan ChenKeishi Kubo
May 14, 2009·Journal of Bone and Mineral Metabolism·David E RothemRami Eliakim
Mar 3, 2010·Orthopedics·Yasumitsu AjiroTakeshi Ogawa
Aug 21, 2010·Cancer Causes & Control : CCC·Glorian SorensenLorraine Wallace
Oct 5, 2010·The Journal of the American Dental Association·Manish AroraEmily Banks
Jan 25, 2011·Trends in Pharmacological Sciences·Riccardo Polosa, Neal L Benowitz
May 21, 2011·Journal of Toxicology and Environmental Health. Part a·Abdelhabib SemlaliMahmoud Rouabhia
Dec 14, 2011·PloS One·Beata KosmiderRobert J Mason
Jan 21, 2012·Inhalation Toxicology·Shahnaz BakandFinance Dechsakulthorn
Feb 1, 2012·The Nursing Clinics of North America·Carol A RikerEllen J Hahn
May 2, 2012·The Journal of the American Dental Association·Juliana Zavala BazziEvelise Machado de Souza
Oct 19, 2013·International Journal of Environmental Research and Public Health·Konstantinos E FarsalinosVassilis Voudris
Jan 1, 2014·International Journal of Hygiene and Environmental Health·Wolfgang SchoberHermann Fromme
Jan 9, 2014·JAMA : the Journal of the American Medical Association·Marie NgEmmanuela Gakidou
Mar 15, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Sebastián L VegaPrabhas V Moghe
Nov 3, 2015·The Journal of Contemporary Dental Practice·Claudio MarcantonioDaniela Leal Zandim-Barcelos
Nov 11, 2015·Journal of Dental Research·M NagasawaK Uoshima
Apr 27, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Muhannad MalasRoberta Ferrence
May 14, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Shigehisa UchiyamaNaoki Kunugita
Jun 9, 2016·Tobacco Control·Lamberto ManzoliUNKNOWN ISLESE Working Group
Jul 5, 2016·Addictive Behaviors·Melanie RoysJames MacKillop
Oct 22, 2016·Evidence-based Dentistry·Susan J Carson, Jacqueline Burns
May 5, 2017·Inhalation Toxicology·Laura J LeslieLindsay J Marshall
Aug 18, 2017·Environmental Science & Technology·Skylar KlagerJoseph G Allen
Sep 9, 2017·BMC Public Health·Thomas E SussanShyam Biswal
Sep 12, 2017·Preventive Medicine·Seth M NoarNoel T Brewer
Sep 13, 2017·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Alan PhungSilvia Alessi-Severini
Sep 29, 2017·International Journal of Environmental Research and Public Health·IfeanyiChukwu O OnorDaniel F Sarpong

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Citations

Jan 24, 2019·International Journal of Environmental Research and Public Health·Humidah AlanaziMahmoud Rouabhia
Dec 11, 2019·Toxics·Gozde Isik AndrikopoulosKonstantinos Poulas
Nov 12, 2020·American Journal of Physiology. Cell Physiology·Brandon NguyenNan Xiao
Jan 12, 2021·Australian Dental Journal·K BriggsO Breik
May 7, 2021·Journal of Inflammation·Thomas NicholsonSimon W Jones
Jul 18, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Chaozhen ChenGuoli Yang

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