Cigarette smoke and glutathione: Focus on in vitro cell models

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Isabella Dalle-DonneAldo Milzani

Abstract

Cigarette smoke (CS) is one of the most important preventable risk factors for the development of respiratory diseases, cardiovascular diseases, stroke, and various types of cancer. Due to its high intracellular concentration and central role in maintaining the cellular redox state, glutathione (GSH) is one of the key players in several enzymatic and non-enzymatic reactions necessary for protecting cells against CS-induced oxidative stress. A plethora of in vitro cell models have been used over the years to assess the effects of CS on intracellular GSH and its disulphide forms, i.e. glutathione disulphide (GSSG) and S-glutathionylated proteins. In this review, we described the effects of cell exposure to CS on cellular GSH and formation of its oxidized forms and adducts (GSH-conjugates). We also discussed the limitations and relevance of in vitro cell models of exposure to CS and critically assessed the congruence between smokers and in vitro cell models. What emerges clearly is that results obtained in vitro should be interpreted with extreme caution, bearing in mind the limitations of the specific cell model used. Despite this, in vitro cell models remain important tools in the assessment of CS-induced oxidative damage.

References

Aug 31, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·J P Kehrer, S S Biswal
Apr 12, 2003·FEBS Letters·Barry Halliwell
Jul 29, 2003·The European Respiratory Journal·C NeurohrJ Behr
Oct 2, 2003·The Biochemical Journal·Gábor BánhegyiAngelo Benedetti
Dec 19, 2003·Free Radical Biology & Medicine·Siobhan E MoriartyPaul Sternberg
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jung H SuhTory M Hagen
Feb 28, 2004·The Journal of Nutrition·Guoyao WuNancy D Turner
Jun 7, 2005·Ageing Research Reviews·Pamela Maher
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Maddalena FratelliPietro Ghezzi
Feb 25, 2006·American Journal of Respiratory and Critical Care Medicine·André M CantinPeter Durie
May 9, 2006·Antioxidants & Redox Signaling·Irfan RahmanSaibal K Biswas
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Isabella Dalle-DonneAldo Milzani
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Sep 30, 2006·Molecular Human Reproduction·Mark SullivanSania Latif
Nov 3, 2006·American Journal of Respiratory Cell and Molecular Biology·Dirk-Jan SlebosAugustine M K Choi
May 1, 2007·Annual Review of Nutrition·Xin Gen LeiJames P McClung
May 15, 2007·Chest·Dilyara G YanbaevaEmiel F M Wouters
Aug 11, 2007·The Journal of Biological Chemistry·Angela K ZimmermannDaniel A Linseman
Sep 22, 2007·Critical Care Medicine·Gianni BioloMarcello De Cicco
Oct 30, 2007·Blood Cells, Molecules & Diseases·Daniela GiustariniRanieri Rossi
Jun 5, 2008·Antioxidants & Redox Signaling·Dunyaporn TrachoothamPeng Huang
Jul 8, 2008·Molecular Aspects of Medicine·Shelly C Lu
Jul 16, 2008·Journal of Cellular and Molecular Medicine·R RossiI Dalle-Donne
Sep 13, 2008·Molecular Aspects of Medicine·Nazzareno BallatoriChristine L Hammond
Sep 25, 2008·Molecular Aspects of Medicine·Christopher C FranklinTerrance J Kavanagh
Jan 2, 2009·Chest·Gaetan DesleeRichard A Pierce
Jan 13, 2009·Trends in Biochemical Sciences·Isabella Dalle-DonneAldo Milzani
Jan 27, 2009·Biological Chemistry·Nazzareno BallatoriChristine L Hammond
Feb 24, 2009·Molecular Aspects of Medicine·Federico V PallardóJosé Viña
Aug 18, 2009·American Journal of Respiratory Cell and Molecular Biology·Hongqiao Zhang, Henry Jay Forman
Aug 19, 2009·Antioxidants & Redox Signaling·Graziano ColomboIsabella Dalle-Donne
Nov 19, 2009·Respiratory Research·Brendan J CarolanRonald G Crystal
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Michael D JohnsonPeter G Shields
Dec 17, 2009·American Journal of Respiratory Cell and Molecular Biology·Gaetan DesleeRichard A Pierce
Jan 12, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Linsey E HaswellMarianna D Gaça
Mar 12, 2010·Accounts of Chemical Research·Aaron T Jacobs, Lawrence J Marnett
Mar 25, 2010·The Journal of Biological Chemistry·Cecile M KrejsaTerrance J Kavanagh
May 8, 2010·Nature Reviews. Cancer·UNKNOWN American Type Culture Collection Standards Development Organization Workgroup ASN-0002
Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Neal S GouldBrian J Day
Jul 27, 2010·Veterinary Pathology·L H Lash
Sep 8, 2010·Free Radical Research·Isabella Dalle-DonneAldo Milzani

❮ Previous
Next ❯

Citations

May 1, 2021·Nutrition Research Reviews·Emanuela AstoriIsabella Dalle-Donne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
E HasnisA Z Reznick
Anticancer Research
Christina PiperiMiltiades C Psallidopoulos
Toxicological Sciences : an Official Journal of the Society of Toxicology
Neal S GouldBrian J Day
American Journal of Respiratory and Critical Care Medicine
Neal S GouldBrian J Day
© 2021 Meta ULC. All rights reserved