Abstract
It is known that smokers have a higher risk of developing cardiovascular disease and lung cancer. Plasma carotenoid concentrations in smokers are generally lower than in non-smokers and this may be due to modifications in diet or a direct or indirect action of cigarette smoke on carotenoids in the plasma. Recently it was reported that reactive nitrogen species derived from cigarette smoke could diffuse across the lung alveolar cell wall into the plasma. Such species may modify circulating low density lipoprotein (LDL) and in the process reduce circulating carotenoid concentrations. In an effort to address this rational we have treated lycopene solutions, human plasma and isolated LDL with cigarette smoke and monitored all-(E)-lycopene, 5(Z)-lycopene and beta-carotene depletion. In plasma, the depletion of all-(E)-lycopene (15.0+/-11.0%, n=10) was greater than 5(Z)-lycopene (10.4+/-9.6%) or beta-carotene (12.4+/-10.5%). In LDL, both all-(E)- and 5(Z)-lycopene were more susceptible than beta-carotene (20.8+/-11.8%, 15.4+/-11.5% and 11.5+/-12.5%, n=3 respectively). The effects have been compared with Sin-1 reactions and isomerization of all-(E) lycopene is common to both treatments. The results clearly indicate that low plasma lyc...Continue Reading
References
Nov 1, 1995·Circulation·J HungG Letchacovski
Jul 1, 1996·Atherosclerosis·J M GrahamD Billington
Jul 1, 1996·Chemical Research in Toxicology·J S Beckman
Mar 27, 1999·Thrombosis Research·Y FusegawaY Ando
Jun 16, 1999·Chemical Research in Toxicology·D L BakerD C Liebler
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
Sep 27, 2002·Toxicology·Anthony Alberg
Aug 30, 2003·BMJ : British Medical Journal·Michael J Thun
Sep 19, 2003·Lancet·Majid Ezzati, Alan D Lopez
Mar 3, 2004·Archives of Biochemistry and Biophysics·Peter C Dedon, Steven R Tannenbaum
Nov 17, 2004·Current Drug Metabolism·Akiyoshi NishikawaMasao Hirose
Jul 30, 2005·Atherosclerosis·Masafumi KuzuyaHiroshi Shimokata
May 17, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Helen E GabrielElizabeth J Johnson
Mar 3, 2007·Journal of Pharmacological Sciences·Yu YamaguchiMasaru Kunitomo
Citations
Apr 30, 2014·Journal of Molecular Modeling·Ajit Kumar Prasad, Phool C Mishra
Apr 20, 2012·Free Radical Research·Daniel L GrahamGordon M Lowe
Sep 20, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Assunta CatalanoPaola Palozza
Feb 13, 2015·Critical Reviews in Food Science and Nutrition·Lars MüllerVolker Böhm
Sep 14, 2017·Antioxidants·Daniel L GrahamGordon M Lowe
Jan 29, 2016·The American Journal of Clinical Nutrition·Rebecca E GraffLorelei A Mucci
Oct 3, 2018·Nutrients·Renata LucasRalph Rühl