Cigarette smoke condensate and total particulate matter severely disrupts physiological angiogenesis

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Sohail EjazBumseok Kim

Abstract

The cigarette smoke condensate (CSC) and total particulate matter (TPM) in cigarette smoke is extremely toxic and may produce several pathologies. In our study, we used a chicken chorioallantoic membrane assay (CAM) to study the toxicological effects of CSC and TPM on different aspects of angiogenesis. CSC and TPM from four different commercial filtered cigarettes were applied to the CAMs on day 6 of incubation. Macroscopic vascular transformations were observed among all treated CAMs. The application of CSC disks caused obliteration of main blood vessels, while the entire architecture of the secondary and tertiary vasculature was completely destroyed. Likewise, the application of TPM from all brands of cigarette caused the disproportionate thinning of all primary and secondary blood vessels. A reduction in the total area and diameter of the primary, secondary, and tertiary blood vessels was observed after treatment with CSC and TPM. Histological evaluations revealed the loss of ectodermal and mesodermal integrity with both types of treatments. We also noted a profound inflammatory reaction restricted to the disk area with a novel filopodial deformity of the endoderm in the CSC treated groups. Scanty capillary plexus formation,...Continue Reading

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Citations

Dec 3, 2014·Annales de chirurgie plastique et esthétique·I PluvyB Chaput
Jun 13, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Anas A AshourAla-Eddin Al Moustafa
May 31, 2020·Toxics·Anas AshourAla-Eddin Al Moustafa
Jul 22, 2018·Scientific Reports·Marjorie AlvarezJosé T Egaña

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