Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Miki ShizuKikuo Onozaki

Abstract

Rheumatoid arthritis (RA) is characterized by proliferation of synoviocytes that produce proinflammatory cytokines, which are implicated in the pathogenesis of RA. When human fibroblast-like synoviocytes line MH7A was treated with cigarette smoke condensate (CSC), either mainstream or sidestream, expression levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, and CYP1A1 mRNA were upregulated in both time- and dose-dependent manners. The upregulatory effects of CSC on these cytokines were not significantly inhibited by alpha-naphthoflavone, an aryl hydrocarbon receptor (AhR) antagonist, suggesting that the effects of CSC were independent of AhR. Cycloheximide treatment indicated that the augmenting effect of CSC on IL-1alpha, IL-1beta and IL-8, but not IL-6 and CYP1A1, mRNA expression requires de novo protein synthesis. CSC also induced cytokines at protein levels and further augmented the effects of tumor necrosis factor alpha on induction of these cytokines at both mRNA and protein levels. These results support the epidemiological studies indicating a strong association between heavy cigarette smoking and pathogenesis of RA.

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Citations

Sep 13, 2014·Tobacco Induced Diseases·Lascelles Lyn-CookGeorge Hammons
Mar 7, 2013·Der Internist·E Decker, U Müller-Ladner
Jun 14, 2013·Critical Reviews in Clinical Laboratory Sciences·Daniela CretuVinod Chandran
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Jun 5, 2018·Biological & Pharmaceutical Bulletin·Masafumi TakenoTakemasa Takii
Aug 27, 2017·Clinical Rheumatology·Nevin Hammam, Tamer A Gheita

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