Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract.

Mucosal Immunology
Joshua J C McGrathMartin R Stämpfli

Abstract

The upper respiratory tract is highly exposed to airborne pathogens and serves as an important inductive site for protective antibody responses, including mucosal IgA and systemic IgG. However, it is currently unknown to what extent inhaled environmental toxins, such as a cigarette smoke, affect the ability to induce antibody-mediated immunity at this site. Using a murine model of intranasal lipopolysaccharide and ovalbumin (LPS/OVA) immunization, we show that cigarette smoke exposure compromises the induction of antigen-specific IgA in the upper airways and systemic circulation. Deficits in OVA-IgA were observed in conjunction with a reduced accumulation of OVA-specific IgA antibody-secreting cells (ASCs) in the nasal mucosa, inductive tissues (NALT, cervical lymph nodes, spleen) and the blood. Nasal OVA-IgA from smoke-exposed mice also demonstrated reduced avidity during the acute post-immunization period in association with an enhanced mutational burden in the cognate nasal Igha repertoire. Mechanistically, smoke exposure attenuated the ability of the nasal mucosa to upregulate VCAM-1 and pIgR, suggesting that cigarette smoke may inhibit both nasal ASC homing and IgA transepithelial transport. Overall, these findings demonst...Continue Reading

References

May 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·K R Bennet, P C Reade
Jan 1, 1982·International Archives of Allergy and Applied Immunology·R RylanderP Haglind
Jan 8, 1999·European Journal of Oral Sciences·G Norhagen Engström, P E Engström
Dec 26, 2001·The Journal of Experimental Medicine·M ShimodaT Takemori
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·D S SouthamM D Inman
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva GärdbyNils Lycke
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn B RenegarPeter F Wright
Sep 3, 2004·Nature Reviews. Immunology·Hiroshi Kiyono, Satoshi Fukuyama
Nov 10, 2004·Archives of Internal Medicine·Lidia Arcavi, Neal L Benowitz
Dec 17, 2008·Mucosal Immunology·A J MacphersonP Brandtzaeg
Mar 31, 2009·Nature Reviews. Immunology·Martin R Stämpfli, Gary P Anderson
Mar 20, 2010·Journal of Reproductive Immunology·Jiri MesteckyZina Moldoveanu
Oct 5, 2010·The Lancet Infectious Diseases·Jean-Pierre AmorijAnke Huckriede
Jul 26, 2012·Nature Reviews. Immunology·Nils Lycke
Sep 25, 2012·Vaccine·Christopher S AmbroseRaburn M Mallory
Jul 23, 2013·Frontiers in Immunology·Blaise Corthésy
Feb 8, 2014·BMC Immunology·Maria Rita GiucaGiuseppe Marzo
Feb 12, 2015·Mucosal Immunology·H LeeS Mehandru
Feb 12, 2015·The New England Journal of Medicine·Brian D CarterEric J Jacobs
Jun 13, 2015·Bioinformatics·Namita T GuptaSteven H Kleinstein
Aug 5, 2016·Nature Protocols·M A TurchaninovaD M Chudakov
Oct 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ang CuiSteven H Kleinstein
Dec 3, 2016·American Journal of Respiratory and Critical Care Medicine·Vasiliy V PolosukhinTimothy S Blackwell
Jan 28, 2017·Scientific Reports·Michiru NishitaYasuhiro Minami
Aug 30, 2019·The Journal of Infection·H LawrenceT McKeever
Oct 24, 2020·American Journal of Respiratory Cell and Molecular Biology·Meghan E RebuliIlona Jaspers

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