Cigarette Smoke-Induced Acquired Dysfunction of Cystic Fibrosis Transmembrane Conductance Regulator in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Oxidative Medicine and Cellular Longevity
Juan ShiXiaoming Liu

Abstract

Chronic obstructive pulmonary disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible. Cigarette smoke and oxidative stress are main etiological risks in COPD. Interestingly, recent studies suggest a considerable overlap between chronic bronchitis (CB) phenotypic COPD and cystic fibrosis (CF), a common fatal hereditary lung disease caused by genetic mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Phenotypically, CF and COPD are associated with an impaired mucociliary clearance and mucus hypersecretion, although they are two distinct entities of unrelated origin. Mechanistically, the cigarette smoke-increased oxidative stress-induced CFTR dysfunction is implicated in COPD. This underscores CFTR in understanding and improving therapies for COPD by altering CFTR function with antioxidant agents and CFTR modulators as a great promising strategy for COPD treatments. Indeed, treatments that restore CFTR function, including mucolytic therapy, antioxidant ROS scavenger, CFTR stimulator (roflumilast), and CFTR potentiator (ivacaftor), have been tested in COPD. This review article is aimed at summarizing the molecular, cellular, and clinical evidence of oxidativ...Continue Reading

References

Sep 1, 1992·The American Review of Respiratory Disease·S AkaiT Takishima
Jun 25, 2004·The New England Journal of Medicine·James C HoggPeter D Paré
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Aleksandra DivacDragica Radojkovic
Feb 16, 2005·Annual Review of Physiology·John R Riordan
Sep 16, 2005·American Journal of Physiology. Cell Physiology·André M CantinJohn W Hanrahan
Jan 20, 2006·The Journal of Biological Chemistry·Lan ChenSadis Matalon
Feb 14, 2006·Current Pharmaceutical Design·Frédéric Becq
Feb 25, 2006·American Journal of Respiratory and Critical Care Medicine·André M CantinPeter Durie
Jan 19, 2008·Molecular Nutrition & Food Research·Jan F Stevens, Claudia S Maier
Jul 26, 2008·Genetic Testing·Marija StankovicDragica Radojkovic
Dec 19, 2008·Annales de biologie clinique·N PongnimitprasertF Braut-Boucher
Oct 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fredrick Van GoorPaul Negulescu
Mar 20, 2010·The Clinical Respiratory Journal·Morten Dahl
Apr 7, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jessica RennoldsEstelle Cormet-Boyaka
Oct 30, 2010·Proceedings of the American Thoracic Society·André M Cantin
Dec 3, 2010·The New England Journal of Medicine·John V Fahy, Burton F Dickey
Dec 8, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manish BodasNeeraj Vij
Mar 8, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Manish BodasNeeraj Vij
Aug 23, 2011·Bioorganic & Medicinal Chemistry Letters·Xicheng SunGary J Rosenthal
Oct 13, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lucy A ClunesRobert Tarran
Aug 11, 2012·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboRoberto Rodriguez-Roisin
Dec 4, 2012·American Journal of Respiratory and Critical Care Medicine·Victor Kim, Gerard J Criner
Dec 12, 2012·PloS One·Fatemat HassanEstelle Cormet-Boyaka
Feb 19, 2013·Biochimica Et Biophysica Acta·Katarzyna A BroniowskaNeil Hogg
Jul 6, 2013·Pulmonary Pharmacology & Therapeutics·Caroline NorezClarisse Vandebrouck
Jul 24, 2013·The Journal of Physiology·Carey A HobbsRobert Tarran
Aug 13, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andras RabJames F Collawn
Sep 18, 2013·American Journal of Respiratory and Critical Care Medicine·S Vamsee RajuSteven M Rowe
Oct 11, 2013·American Journal of Respiratory Cell and Molecular Biology·James A LambertSteven M Rowe
Jan 23, 2014·The Journal of Biological Chemistry·Julia E RasmussenRobert Tarran
Feb 13, 2014·Respiratory Research·S Vamsee RajuSteven M Rowe
Feb 13, 2014·Basic & Clinical Pharmacology & Toxicology·Katharine H Abbott-Banner, Clive P Page
Jun 25, 2014·Respiratory Research·Fatemat HassanEstelle Cormet-Boyaka
Aug 8, 2014·Science Translational Medicine·Deborah M CholonMartina Gentzsch

❮ Previous
Next ❯

Citations

Oct 12, 2018·American Journal of Physiology. Cell Physiology·Scott M O'Grady
Apr 25, 2020·International Journal of Molecular Sciences·Patricia ScottRobert Cormier
Dec 20, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Kai Ling ChinArmando Acosta
Oct 23, 2019·World Journal of Gastroenterology : WJG·Kyle J AndersonPatricia M Scott
Dec 1, 2019·Molecular Cancer Therapeutics·Ryosuke TaninoTakeshi Isobe
Sep 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R K DuttaH J Unwalla

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
pharmacotherapy

Related Concepts

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.