Cigarette smoke-induced bronchoconstriction: causative agents and role of thromboxane receptors

Journal of Applied Physiology
J L Hong, L Y Lee

Abstract

Inhalation of cigarette smoke induces a biphasic bronchoconstriction in guinea pigs: the first phase is induced by a combination of cholinergic reflex and tachykinins, whereas the second phase involves cyclooxygenase metabolites (J.-L. Hong, I. W. Rodger, and L.-Y. Lee. J. Appl. Physiol. 78: 2260-2266, 1995). This study was carried out to further determine the causative agents in the smoke and the types of prostanoid receptors and endogenous prostanoids mediating the bronchoconstriction. Inhalation of 10 ml of high-nicotine cigarette smoke consistently elicited the biphasic bronchoconstriction in anesthetized and artificially ventilated guinea pigs. Pretreatment with hexamethonium (10 mg/kg iv) significantly reduced the first-phase bronchoconstriction but did not have any measurable effect on the second-phase response. In sharp contrast, gas-phase smoke did not elicit any bronchoconstrictive effect. Furthermore, when the animals were challenged with low-nicotine cigarette smoke, only a single second-phase response was evoked, accompanied by increases in thromboxane (Tx) B2 (a stable metabolite of TxA2), prostaglandin (PG) D2, PGF2 alpha in the bronchoalveolar lavage fluid. The bronchoconstrictive response induced by low-nicotin...Continue Reading

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Citations

Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·M IidaH Fujiwara
Aug 22, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennings XuLu-Yuan Lee
Oct 17, 2015·American Journal of Industrial Medicine·Nadia Spada FioriDavid C Christiani
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·Z X WuL Y Lee
Jun 15, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mehmet UnluMustafa Serteser
Apr 8, 1999·Journal of Applied Physiology·T IshikawaG Sant'Ambrogio
Sep 29, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Patrudu MakenaG L Prasad
May 19, 2021·Archives of Biochemistry and Biophysics·Niyati A BorkarChristina M Pabelick
Dec 15, 2010·Biochimica Et Biophysica Acta·Run-Yue Huang, George G Chen

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