Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent

The Journal of Immunology : Official Journal of the American Association of Immunologists
Emilie DozIsabelle Couillin

Abstract

Acute cigarette smoke exposure of the airways (two cigarettes twice daily for three days) induces acute inflammation in mice. In this study, we show that airway inflammation is dependent on Toll-like receptor 4 and IL-1R1 signaling. Cigarette smoke induced a significant recruitment of neutrophils in the bronchoalveolar space and pulmonary parenchyma, which was reduced in TLR4-, MyD88-, and IL-1R1-deficient mice. Diminished neutrophil influx was associated with reduced IL-1, IL-6, and keratinocyte-derived chemokine levels and matrix metalloproteinase-9 activity in the bronchoalveolar space. Further, cigarette smoke condensate (CSC) induced a macrophage proinflammatory response in vitro, which was dependent on MyD88, IL-1R1, and TLR4 signaling, but not attributable to LPS. Heat shock protein 70, a known TLR4 agonist, was induced in the airways upon smoke exposure, which probably activates the innate immune system via TLR4/MyD88, resulting in airway inflammation. CSC-activated macrophages released mature IL-1beta only in presence of ATP, whereas CSC alone promoted the TLR4/MyD88 signaling dependent production of IL-1alpha and pro-IL-1beta implicating cooperation between TLRs and the inflammasome. In conclusion, acute cigarette exp...Continue Reading

References

Aug 6, 1999·Immunity·T KawaiS Akira
Jun 10, 2000·Chest·R Pauwels
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·S D Shapiro
Feb 12, 2002·The Journal of Biological Chemistry·Alexzander AseaStuart K Calderwood
Feb 14, 2002·The Journal of Biological Chemistry·Ramunas M VabulasHermann Wagner
Dec 24, 2002·Current Opinion in Immunology·Shizuo Akira
Oct 30, 2003·The European Respiratory Journal·P J BarnesR A Pauwels
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isabelle CouillinBernhard Ryffel
Sep 15, 2004·European Journal of Pharmacology·Paulo CastroVera Lucia Gonçalves Koatz
Dec 17, 2004·Pharmacological Reviews·Peter J Barnes
Feb 22, 2005·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S MoletV Lagente
Apr 2, 2005·Nature Reviews. Immunology·Michael T Lotze, Kevin J Tracey
Jun 22, 2005·Trends in Immunology·Fabio Martinon, Jürg Tschopp
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia Schnyder-CandrianBruno Schnyder
Oct 26, 2005·Nature Medicine·Dianhua JiangPaul W Noble
Nov 4, 2005·American Journal of Physiology. Cell Physiology·Jong Sung ParkEdward Abraham
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas NoulinIsabelle Couillin
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Mar 3, 2006·The European Respiratory Journal·O LeclercF Schmidlin
Mar 23, 2006·Annual Review of Immunology·Bruce BeutlerKasper Hoebe
Jul 1, 2006·Journal of Leukocyte Biology·Dieudonnée TogbeValerie F J Quesniaux
Aug 31, 2006·International Archives of Allergy and Immunology·Tania MaesGuy G Brusselle
Dec 19, 2006·Biochemical and Biophysical Research Communications·Xiangde Liu

❮ Previous
Next ❯

Citations

Oct 22, 2008·American Journal of Respiratory Cell and Molecular Biology·Andrew ChurgJoanne L Wright
Nov 18, 2008·American Journal of Respiratory and Critical Care Medicine·Mark J Paul-ClarkJane A Mitchell
Feb 8, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R B GonçalvesF H Nociti
Feb 22, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Wenxin WuJordan P Metcalf
Mar 1, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kostas TriantaphyllopoulosKian Fan Chung
Apr 18, 2012·British Journal of Pharmacology·Maria B SukkarSimon Phipps
Oct 12, 2013·American Journal of Respiratory Cell and Molecular Biology·Toru NyunoyaYohannes Tesfaigzi
Sep 23, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Pinar KuruOzgur Kasimay
May 23, 2015·Thorax·Elise G De SmetKen R Bracke
Mar 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitsuo HashimotoStephen L Nishimura
Jun 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitsuo HashimotoStephen L Nishimura
Oct 9, 2015·Medicine·Daniele MinervinoRaffaele Landolfi
Jul 5, 2017·Experimental and Therapeutic Medicine·Bin Wang, Cunbing Wu
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tania MaesGuy G Brusselle
Jan 19, 2010·Annual Review of Pathology·Jun Araya, Stephen L Nishimura
Feb 6, 2010·American Journal of Respiratory and Critical Care Medicine·Gregory T MotzMichael T Borchers
Jul 21, 2011·Journal of Oncology·John L Pauly, Geraldine Paszkiewicz
Apr 13, 2011·PloS One·Katherine Joanne BainesPeter Gerard Gibson
Sep 29, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Daisuke KinoseMichiaki Mishima
Jul 14, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kara S DavisCarl Atkinson
Feb 8, 2011·American Journal of Respiratory Cell and Molecular Biology·Saleela M RuwanpuraBrendan J Jenkins
Jan 11, 2011·Journal of Clinical Periodontology·John B MatthewsIain L C Chapple
Jan 17, 2012·American Journal of Respiratory and Critical Care Medicine·Jin-Fu XuUNKNOWN COPDGene Investigators
Jan 19, 2010·Nature Reviews. Immunology·John E Sims, Dirk E Smith
Oct 22, 2009·American Journal of Respiratory Cell and Molecular Biology·Kazutetsu Aoshiba, Atsushi Nagai
Sep 28, 2013·Expert Review of Clinical Immunology·Rosa FanerAlvar Agusti
Mar 28, 2013·Mediators of Inflammation·Carian E BoorsmaBarbro N Melgert
Nov 18, 2011·Mucosal Immunology·S KeelyP M Hansbro
Feb 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabina HalappanavarMartin Stampfli
Apr 27, 2013·Cellular and Molecular Life Sciences : CMLS·Christina UlmSebastian P Galuska
Aug 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharen ProvoostKurt G Tournoy

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