Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma.

International Journal of Cancer. Journal International Du Cancer
Yiping HuangMyoung Sook Kim

Abstract

Esophageal squamous cell carcinoma (ESCC) is the sixth most frequent cause of cancer death in the world, and cigarette smoke is a key factor in esophageal carcinogenesis. To identify molecular changes during cigarette smoke-induced ESCC, we examined the methylation status of 13 gene promoters in the human immortalized, nontumorigenic esophageal epithelial cell line (Het-1A) that were exposed to mainstream (MSE) or sidestream cigarette smoke extract (SSE) for 6 months in culture. The promoter of sequence-specific single-stranded DNA-binding protein 2 (SSBP2) was methylated in the Het-1A cells exposed to MSE (MSE-Het-1A). Promoter methylation (86%, 56/70) and downregulation of SSBP2 expression were frequently detected in tumor tissues from ESCC patients. In addition, reintroduction of SSBP2 in an ESCC cell line (TE1) that does not express SSBP2 and in the MSE-Het-1A cells inhibited expression of LRP6 and Dvl3, which are mediators of the Wnt signaling pathway. SSBP2 expression markedly decreased the colony-forming ability of ESCC cell lines and significantly inhibited cell growth of the MSE-Het-1A cells. Our results indicate that cigarette smoking is a cause of SSBP2 promoter methylation and that SSBP2 harbors a tumor suppressive ...Continue Reading

References

May 1, 1990·Cancer Genetics and Cytogenetics·N B Atkin, M F Fox
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M VisserF Baas
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·P PisaniJ Ferlay
Jun 28, 2000·Journal of Cancer Research and Clinical Oncology·Y SuzukiH Tsujii
Nov 1, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N Barker, H Clevers
Nov 18, 2000·Journal of the National Cancer Institute·K KawakamiS J Meltzer
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·D YanL T Williams
Nov 8, 2001·Carcinogenesis·G D Stoner, A Gupta
Mar 26, 2004·American Journal of Obstetrics and Gynecology·Jayanthi S LeaCarolyn Y Muller
Apr 7, 2004·Neuro-Signals·Wen Luo, Sheng-Cai Lin
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Dec 2, 2004·Mutation Research·Kirsti Husgafvel-Pursiainen
Dec 2, 2004·Mutation Research·David M DeMarini
Mar 1, 2005·Journal of Clinical Pathology·S Salahshor, J R Woodgett
Jan 13, 2006·The EMBO Journal·Nicolas GoardonTrang Hoang
Dec 22, 2006·PloS One·Hassan Lemjabbar-AlaouiCarol Basbaum
Mar 21, 2007·Digestive Diseases and Sciences·H AshktorabF M Giardiello
Aug 30, 2007·Cancer Metastasis Reviews·Ceshi Chen, Lydia E Matesic
Oct 10, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Elisavet GeorgiouSofia Kouidou
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Myoung Sook KimDavid Sidransky
Feb 28, 2008·International Journal of Cancer. Journal International Du Cancer·Hannah Lui ParkDavid Sidransky
Apr 17, 2008·Cancer Research·Mohammad Obaidul HoqueDavid Sidransky
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun-Wei LiuDavid Sidransky
Jul 12, 2008·Genes, Chromosomes & Cancer·Jennifer L PoitrasCynthia C Morton
Apr 9, 2009·Cancer Research·Mustafa HussainDavid S Schrump
Nov 26, 2009·International Journal of Cancer. Journal International Du Cancer·Myoung Sook KimDavid Sidransky

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Citations

Jun 12, 2013·Carcinogenesis·Zdenko HercegChristopher P Wild
Apr 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuanyuan XiaoMargaret R Wrensch
Oct 20, 2012·PloS One·Elizabeth JiménezWeihong Tan
May 16, 2014·Gastroenterology Research and Practice·Christina MichailidiRafael Guerrero-Preston
Oct 25, 2013·International Review of Psychiatry·Esther WaltonStefan Ehrlich
Sep 11, 2012·International Journal of Cancer. Journal International Du Cancer·Tomoharu MiyashitaTetsuo Ohta
Jul 30, 2014·Future Oncology·Luciane Tsukamoto KagoharaRafael Guerrero-Preston
May 4, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Lutz P Breitling
Jun 4, 2020·Environmental Science and Pollution Research International·Mohammad Mahdi ForghanifardMohammad Reza Abbaszadegan
Jan 21, 2017·Biomedical Reports·Samuel N UwaezuokeChioma L Odimegwu
Nov 9, 2019·Seminars in Cell & Developmental Biology·Saharnaz SarlakRodrigue Rossignol
Apr 4, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Michael M MarshallAdam R Hall

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