Cigarette smoke retention and bronchodilation in patients with COPD. A controlled randomized trial

Respiratory Medicine
Wouter D van DijkTjard R J Schermer

Abstract

Bronchodilators are the cornerstone for symptomatic treatment of chronic obstructive pulmonary disease (COPD). Many patients use these agents while persisting in their habit of cigarette smoking. We hypothesized that bronchodilators increase pulmonary retention of cigarette smoke and hence the risk of smoking-related (cardiovascular) disease. Our aim was to investigate if bronchodilation causes increased pulmonary retention of cigarette smoke in patients with COPD. A double-blinded, placebo-controlled, randomized crossover trial, in which COPD patients smoked cigarettes during undilated conditions at one session and maximal bronchodilated conditions at the other session. Co-primary outcomes were pulmonary tar and nicotine retention. We performed a secondary analysis that excludes errors due to possible contamination. Secondary outcomes included the biomarkers C-reactive protein and fibrinogen, and smoke inhalation patterns. Of 39 randomized patients, 35 patients completed the experiment and were included in the final analysis. Bronchodilation did not significantly increase tar retention (-4.5%, p = 0.20) or nicotine retention (-2.6%, p = 0.11). Secondary analysis revealed a potential reduction of retention due to bronchodilatio...Continue Reading

References

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Citations

Sep 26, 2013·International Journal of Environmental Research and Public Health·Clement Kleinstreuer, Yu Feng
Jan 3, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Emmy de JongTjard R J Schermer

Related Concepts

Tobacco tar
Broncholytic Effect
C-reactive protein
Double-Blind Method
Gamma-Fibrinogen
Forced Expiratory Volume Function
Lung
Cigar smoker
Tars
Vital Capacity

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