Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection

Immunity
Jennifer KearleyAlison A Humbles

Abstract

Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease and is presumed to be central to the altered responsiveness to recurrent infection in these patients. We examined the effects of smoke priming underlying the exacerbated response to viral infection in mice. Lack of interleukin-33 (IL-33) signaling conferred complete protection during exacerbation and prevented enhanced inflammation and exaggerated weight loss. Mechanistically, smoke was required to upregulate epithelial-derived IL-33 and simultaneously alter the distribution of the IL-33 receptor ST2. Specifically, smoke decreased ST2 expression on group 2 innate lymphoid cells (ILC2s) while elevating ST2 expression on macrophages and natural killer (NK) cells, thus altering IL-33 responsiveness within the lung. Consequently, upon infection and release, increased local IL-33 significantly amplified type I proinflammatory responses via synergistic modulation of macrophage and NK cell function. Therefore, in COPD, smoke alters the lung microenvironment to facilitate an alternative IL-33-dependent exaggerated proinflammatory response to infection, exacerbating disease.

References

Mar 28, 1998·The Journal of Experimental Medicine·D XuF Y Liew
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·M LöhningT Kamradt
Nov 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H OndaJ Takeda
Mar 23, 2000·The Journal of Experimental Medicine·M J TownsendA N McKenzie
Jun 24, 2003·The American Journal of Pathology·Espen S BaekkevoldJean-Philippe Girard
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Waldiceu A VerriFernando Q Cunha
Aug 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Damo XuFoo Y Liew
Nov 29, 2008·The New England Journal of Medicine·Sanjay Sethi, Timothy F Murphy
Apr 7, 2009·American Journal of Respiratory Cell and Molecular Biology·Jeroen A J VanoirbeekWim Janssens
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Matthew A RankHirohito Kita
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Corinne Cayrol, Jean-Philippe Girard
Feb 16, 2010·The Journal of Allergy and Clinical Immunology·David PréfontaineQutayba Hamid
Apr 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anant MohanRavindra Mohan Pandey
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·April E PriceRichard M Locksley
Oct 5, 2010·American Journal of Respiratory and Critical Care Medicine·Patrick MalliaSebastian L Johnston
Feb 15, 2011·American Journal of Respiratory Cell and Molecular Biology·Fernando M BotelhoMartin R Stämpfli
Apr 27, 2011·Nature Reviews. Rheumatology·Gaby Palmer, Cem Gabay
Sep 3, 2011·European Journal of Immunology·Qianting YangBinfeng Lu
Nov 29, 2011·The Journal of Allergy and Clinical Immunology·Hye Young KimDale T Umetsu
Dec 20, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kyung-Ah ChoYoung Joo Cho
Feb 11, 2012·Science·Weldy V BonillaDaniel D Pinschewer
Jul 4, 2012·Current Opinion in Pharmacology·Emily Hams, Padraic G Fallon
Aug 16, 2013·The Journal of Clinical Investigation·Derek E ByersMichael J Holtzman
Oct 30, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin MacDonaldPhilip Bardin
Jan 23, 2014·Cancer Research·Daniel O VillarrealDavid B Weiner

❮ Previous
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Citations

Jan 17, 2016·Autoimmunity Reviews·Carlo PerriconeYehuda Shoenfeld
Jan 13, 2016·The Journal of Experimental Medicine·Hongkang XiMenno van Lookeren Campagne
Aug 27, 2015·International Immunology·Timotheus Y F Halim
Jun 18, 2015·Immunity·Ari B MolofskyRichard M Locksley
Mar 10, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ronald AndersonMohammed Tikly
Mar 24, 2016·Seminars in Immunopathology·L A Borthwick
Mar 19, 2015·Immunity·Foo Yew Liew
Jan 11, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C PorsbjergV Backer
Sep 15, 2015·Nature Communications·E Suzanne CohenTomas Mustelin
Sep 8, 2015·The Journal of Allergy and Clinical Immunology·Peter J Barnes
Apr 18, 2015·Nature Reviews. Immunology·Lucy Bird
Apr 26, 2016·Nature Immunology·Yoichiro OhneYong-Jun Liu
Apr 21, 2016·Expert Review of Cardiovascular Therapy·Norbert F VoelkelMark R Nicolls
Apr 6, 2016·AIDS·Vikram MehrajUNKNOWN Montreal Primary HIV Infection, the Canadian Long-Term Non-Progressors Study Groups
Jul 2, 2016·Pharmacology & Therapeutics·Patrick D Mitchell, Paul M O'Byrne
Jul 10, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Seong Ho ChoPhilippe Gevaert
Aug 30, 2016·Cellular & Molecular Immunology·Damien Bertheloot, Eicke Latz
Oct 6, 2016·Mediators of Inflammation·Carl D RichardsFernando Botelho
Oct 13, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bernadette JonesPhilip M Hansbro
Oct 19, 2016·Nature Communications·Lauriane Galle-TregerOmid Akbari
Nov 29, 2016·Nature Reviews. Immunology·Akiko IwasakiRyan D Molony
Dec 17, 2016·Nature Immunology·Jennifer L HopePeter D Katsikis
Mar 9, 2017·Arthritis Research & Therapy·Peter OlssonElke Theander
Jun 29, 2017·Immunological Reviews·Hadi Maazi, Omid Akbari
Jun 29, 2017·Immunological Reviews·Kafi N EaleyShigeo Koyasu
Jun 29, 2017·Immunological Reviews·Li Yin Drake, Hirohito Kita
Dec 15, 2015·Physiological Reports·Gilbert F MorrisDeborah E Sullivan
Mar 29, 2018·Respiratory Research·Hiroyuki AizawaMasakazu Ichinose
Feb 25, 2018·Nature Immunology·Etienne PatinUNKNOWN Milieu Intérieur Consortium
Oct 28, 2017·Expert Opinion on Therapeutic Targets·Victor FattoriWaldiceu A Verri
Jul 2, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brandon W LewisYogesh Saini
Feb 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peleg RiderIdan Cohen
Mar 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiacheng BiXiaochun Wan
Apr 21, 2018·Immunology·Thomas ScamblerDaniel Peckham
Dec 17, 2017·Immunological Reviews·Corinne Cayrol, Jean-Philippe Girard
May 1, 2018·Journal of Cell Communication and Signaling·Sneha M PintoAkhilesh Pandey
Sep 22, 2018·Current Opinion in Rheumatology·Laure GallayBaptiste Hervier
Sep 28, 2018·Journal of Leukocyte Biology·Chantal DonovanPhilip M Hansbro
Oct 18, 2016·F1000Research·Gary P Anderson

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