Cigarette smoking and colorectal cancer: a study of 1,584 cases and 2,879 controls

Preventive Medicine
B D'AvanzoR Talamini

Abstract

Although colorectal cancer is not one of the major tobacco-related cancers, a possible association with tobacco has been suggested following the observation of a relationship between cigarette smoking and colorectal adenomas. The issue of a long latency of tobacco on colorectal carcinogenesis has also been suggested, since elevated relative risks were observed in long-term smokers. The association between colorectal cancer and cigarette smoking has been investigated using data from a case-control study conducted in northern Italy between 1985 and 1991 on 955 cases of colon and 629 cases of rectal cancer and 2,879 controls in hospital for acute, nonneoplastic, nondigestive tract, nontobacco-related diseases. Odds ratios (OR), and the corresponding 95% confidence intervals, of colorectal cancer according to various measures of tobacco smoking were derived from multivariate models, including terms for sex, age, total calorie intake and selected dietary variables, alcohol consumption, and family history of colorectal cancer. No association between smoking and colorectal cancer was observed. Compared with people who had never smoked, the overall multivariate OR for colorectal cancer was 0.9 in ex-smokers and 0.7 in current smokers. ...Continue Reading

Citations

Jan 15, 1998·Journal of the National Cancer Institute·J A BaronE R Greenberg
Jul 2, 1999·International Journal of Cancer. Journal International Du Cancer·E NegriS Franceschi
Dec 18, 2001·British Journal of Cancer·V BagnardiG Corrao
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