Cigarette smoking and lung cancer: modeling total exposure and intensity

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Jay H Lubin, Neil Caporaso

Abstract

Investigators typically analyze cigarette smoking using smoking duration and intensity (number of cigarettes smoked per day) as risk factors. However, odds ratios (OR) for categories of intensity either adjusted for, or jointly with, duration of smoking may be distorted by differences in total pack-years of exposure to cigarette smoke. To study effects of intensity, we apply a linear excess OR model to compare total exposure delivered at low intensity for a long period of time with an equal total exposure delivered at high intensity for a short period of time to data from a large case-control study of lung cancer. The excess OR per pack-year increases with intensity for subjects who smoke < or =20 cigarettes per day and decreases with intensity for subjects who smoke >20 cigarettes per day. The intensity patterns are homogeneous by histologic type of lung cancer, suggesting that observed differences in risks by histologic type are related to total smoking exposure or smoking duration and not smoking intensity. At lower smoking intensities, there is an "exposure enhancement" effect such that for equal total exposure, the excess OR per pack-year increases with intensity. At higher smoking intensities, there is a "reduced potency"...Continue Reading

References

Aug 1, 1984·Journal of the National Cancer Institute·J H Lubin, W J Blot
May 15, 1984·International Journal of Cancer. Journal International Du Cancer·J H LubinG Visco
Jan 20, 1998·Cancer Metastasis Reviews·Q Wei, M R Spitz
Jun 4, 1999·American Journal of Epidemiology·B McKnightN S Weiss
Jun 8, 2000·Journal of the National Cancer Institute·M Berwick, P Vineis
Nov 4, 2000·Journal of the National Cancer Institute·Q WeiM R Spitz
Feb 8, 2002·Journal of Epidemiology and Biostatistics·M HauptmannJ Lubin
Oct 25, 2002·American Journal of Epidemiology·Karen LeffondréBernard Rachet
Jan 1, 2003·Carcinogenesis·David H Phillips
Aug 20, 2003·International Journal of Cancer. Journal International Du Cancer·Hongbing ShenQingyi Wei
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Paolo VineisSeymour Garte
Oct 27, 2004·Journal of Dental Research·Th Dietrich, K Hoffmann
Nov 6, 2004·Journal of Clinical Epidemiology·B RachetK Leffondré
Apr 21, 2005·Journal of the National Cancer Institute·Rayjean J HungPaolo Boffetta
Oct 11, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sally W ThurstonDavid C Christiani

❮ Previous
Next ❯

Citations

Jan 6, 2009·Cancer Causes & Control : CCC·Nawi NgHeiko Becher
Oct 23, 2012·Demography·Jessica Y Ho, Irma T Elo
Nov 3, 2009·Journal of Human Genetics·Toshiki OkasakaKazuo Tajima
May 29, 2008·Seminars in Respiratory and Critical Care Medicine·Anthony J Alberg, Jill Nonemaker
Jun 30, 2009·American Journal of Epidemiology·Shannon M LynchRachael Z Stolzenberg-Solomon
Jan 6, 2010·American Journal of Epidemiology·Dario ConsonniMaria Teresa Landi
Nov 18, 2009·Journal of the National Cancer Institute·Dalsu BarisDebra T Silverman
Feb 28, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Tellervo KorhonenJaakko Kaprio
Aug 21, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·José L F AntunesVictor Wünsch-Filho
Feb 28, 2008·Journal of Occupational and Environmental Medicine·Amy M NuernbergDavid C Christiani
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Joshua E MuscatJohn P Richie
Mar 5, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jill KoshiolNeil E Caporaso
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·John L PaulyPeter G Shields
Apr 25, 2008·American Journal of Respiratory and Critical Care Medicine·Sarita Dubey, Charles A Powell
Mar 3, 2012·PloS One·Jill KoshiolMartin J Blaser
Aug 23, 2012·PloS One·Ley-Fang KuaWei-Peng Yong
Jan 28, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Annaka SchulteUNKNOWN Queensland Pancreatic Cancer Study Group
Dec 21, 2013·American Journal of Epidemiology·Duncan C Thomas
Feb 12, 2013·Journal of the American Medical Informatics Association : JAMIA·Laura K WileyWilliam S Bush
Sep 17, 2009·American Journal of Epidemiology·Laurence S FreedmanSiegal Sadetzki
Nov 18, 2008·Inhalation Toxicology·Ambrogio FassinaMassimo Montisci
Feb 2, 2016·Drug Metabolism Reviews·Dong Gui HuRobyn Meech
May 3, 2014·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Soronnadi Clara Ngozi, Neboh Emeka Ernest
Mar 17, 2016·EBioMedicine·Sean P DavidMarcia L Stefanick
Dec 22, 2015·International Journal of Public Health·Raphaël AndlerViêt Nguyen-Thanh
May 19, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E RoemerR A Carchman
Feb 3, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lap Ah TseStephen Chun-Key Law
Sep 16, 2008·Regulatory Toxicology and Pharmacology : RTP·Chao W Chen
Sep 26, 2006·Statistics in Medicine·Karen LeffondréJack Siemiatycki
Dec 2, 2011·International Journal of Cancer. Journal International Du Cancer·Heather P TarletonZuo-Feng Zhang
Aug 10, 2011·Cancer·Joshua E MuscatSteven D Stellman
Feb 17, 2015·Risk Analysis : an Official Publication of the Society for Risk Analysis·Suresh H MoolgavkarRoger McClellan
Sep 15, 2015·The Clinical Respiratory Journal·Nilufer AvciTurkkan Evrensel
Aug 21, 2014·Journal of Exposure Science & Environmental Epidemiology·Frank de VochtNuthchyawach Sanguanchaiyakrit
May 9, 2014·Critical Reviews in Toxicology·Suresh H MoolgavkarDavid G Hoel
Aug 5, 2010·Radiation Research·Kyoji FurukawaKiyohiko Mabuchi
Oct 12, 2015·Atencion primaria·Pilar María González RomeroArmando Aguirre-Jaime

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.