Cigarette smoking and trisomy 21 at amniocentesis

Genetic Epidemiology
J KlineR Hindin

Abstract

Several studies raise the possibility that smoking during pregnancy is associated with a slightly decreased odds of trisomy 21 at birth. If it is, associations may reflect decreased incidence at conception, increased intrauterine loss (at one or several times in gestation), or both. Women (n = 13,729) undergoing prenatal diagnosis completed a questionnaire before learning karyotype results. For each women with a trisomy, up to 4 controls with chromosomally normal pregnancies, matched for age and hospital, were selected. Analyses drew on the 89 trisomy 21-control matched m-tuples in which diagnosis was by amniocentesis at 14-26 weeks. We compared the odds of smoking at last menstrual period and in the past in cases and controls. The odds of current smoking versus never smoking were decreased [adjusted odds ratio = 0.8, 95% confidence interval (CI) 0.4-1.6] and the odds of exsmoking increased (adjusted odds ratio = 1.4, 95% CI 0.9-2.4) in trisomy 21 cases. The association with current smoking was essentially unchanged when the unexposed reference group was defined as exsmokers and women who never smoked (adjusted odds ratio = 0.7, 95% CI 0.4-1.4). These results for current smoking agree well with a summary estimate based on combi...Continue Reading

References

Sep 1, 1990·Prenatal Diagnosis·H S CuckleG Knight
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Aug 20, 1987·The New England Journal of Medicine·D WarburtonJ Kline
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Aug 1, 1986·Teratology·P H ShionoH W Berendes
Jan 1, 1985·Basic Life Sciences·J Kline, Z Stein

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Citations

Dec 29, 2000·American Journal of Epidemiology·C P Torfs, R E Christianson
Jan 1, 1996·Environmental and Molecular Mutagenesis·U Eichenlaub-Ritter
Jan 1, 1997·Genetic Epidemiology·K Källén
Sep 25, 2004·Pediatric Blood & Cancer·Julie A RossAndrew F Olshan
Jun 1, 1997·Teratology·M M Werler
Oct 3, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Stephanie L ShermanSallie B Freeman
Sep 30, 2005·Cytogenetic and Genome Research·S L ShermanN E Lamb
May 5, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Q YangS B Freeman

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