Cigarette smoking as a risk factor for schizophrenia or all non-affective psychoses

Psychological Medicine
Michael KingIrwin Nazareth

Abstract

Smoking tobacco is regarded as an epiphenomenon in patients with schizophrenia when it may be causal. We aimed to examine whether smoking status is related to the onset of schizophrenia or the broader diagnosis of non-affective psychosis, including schizophrenia. We used data from The Health Improvement Network primary care database to identify people aged 15-24 between 1 January 2004 and 31 December 2009. We followed them until the earliest of: first diagnosis of schizophrenia (or psychosis), patient left the practice, practice left THIN, patient died or 31 December 2014. In men, incidence rates for schizophrenia per 100 000 person years at risk were higher in smoking initiators (non-smoker who became a smoker during the study) than in non-smokers (adjusted IRR 1.94; 95% CI 1.29-2.91) and higher still in smokers (adjusted IRR 3.32; 95% CI 2.67-4.14). Among women, the incidence rate of schizophrenia was higher in smokers than in non-smokers (adjusted IRR 1.50; 95% CI 1.06-2.12), but no higher in smoking initiators than non-smokers. For non-affective psychosis, the pattern was similar for men but more evident in women where psychosis incidence rates were higher in smoking initiators (adjusted IRR 1.90; 95% CI 1.40-2.56) and in s...Continue Reading

References

Dec 1, 1995·Journal of Epidemiology and Community Health·S A DolanD Hart
Feb 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Louise ArseneaultRobin M Murray
Aug 16, 2008·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Lisa DierkerKathleen Merikangas
Dec 10, 2008·Pharmacoepidemiology and Drug Safety·Andrew MaguireMary Thompson
May 21, 2009·Pharmacoepidemiology and Drug Safety·Shreya Davé, Irene Petersen
Jan 7, 2010·Current Opinion in Psychiatry·Georg Winterer
Nov 6, 2012·Pharmacoepidemiology and Drug Safety·Laura HorsfallIrene Petersen
Dec 19, 2013·PloS One·Sarah HardoonDavid P J Osborn
Sep 12, 2014·Acta Psychiatrica Scandinavica·C M AguochaG M Onyeama
May 21, 2015·The Australian and New Zealand Journal of Psychiatry·John J McGrathJames G Scott
Aug 1, 2015·The Australian and New Zealand Journal of Psychiatry·Matthew Large, James H MacCabe
Aug 8, 2015·The Lancet. Psychiatry·Pedro GurilloJames H MacCabe
Aug 26, 2015·The Lancet. Psychiatry·David M FergussonL John Horwood
Sep 21, 2015·Biological Psychiatry·Suzanne H GageStanley Zammit
Nov 2, 2015·Drug and Alcohol Dependence·Jason A Ford, Danielle Perna
Nov 18, 2015·The American Journal of Psychiatry·Schahram Akbarian, Marija Kundakovic
Dec 22, 2015·Psychiatry Research·Xiao-Lan CaoYu-Tao Xiang
Feb 18, 2016·Schizophrenia Bulletin·Arianna MarconiEvangelos Vassos
May 14, 2016·Drug and Alcohol Dependence·Marcus R MunafòKenneth Kendler
Feb 24, 2017·Addiction Biology·Gunnar W ReginssonKari Stefansson
Mar 8, 2017·Nature Medicine·Xin-An Liu, Paul J Kenny

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