Cigarette Smoking-Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets
Abstract
Cigarette smoking plays a major role in cardiovascular diseases. The acute effects of cigarette smoking produce central nervous system-mediated activation of the sympathetic nervous system. The overactive sympathetic nervous system stimulates the secretion of serotonin (5-HT) and catecholamine into blood at supraphysiological levels. The correlation between these pathological conditions induced by smoking and the increased risk of thrombosis has not been thoroughly investigated. The goal of our study was to explore cigarette smoking-associated changes in platelet biology mediated by elevated 5-HT and catecholamine levels in blood plasma. Using blood samples collected from healthy nonsmokers and smokers (15 minutes after smoking), we determined that cigarette smoking increased the plasma 5-HT/catecholamine concentration by several fold and the percent aggregation of platelets 2-fold. Liquid chromatography-tandem mass spectrometry analysis of proteins eluted from platelet plasma membranes of smokers and nonsmokers demonstrated that GTPase-activating proteins and proteins participating in the actin cytoskeletal network were differentially and significantly elevated in smokers' platelet membranes compared with those of nonsmokers. ...Continue Reading
References
Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter.
Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages.
Citations
Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
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