Cigarette Smoking-Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets

Journal of the American Heart Association
Curtis Lee LoweryFusun Kilic

Abstract

Cigarette smoking plays a major role in cardiovascular diseases. The acute effects of cigarette smoking produce central nervous system-mediated activation of the sympathetic nervous system. The overactive sympathetic nervous system stimulates the secretion of serotonin (5-HT) and catecholamine into blood at supraphysiological levels. The correlation between these pathological conditions induced by smoking and the increased risk of thrombosis has not been thoroughly investigated. The goal of our study was to explore cigarette smoking-associated changes in platelet biology mediated by elevated 5-HT and catecholamine levels in blood plasma. Using blood samples collected from healthy nonsmokers and smokers (15 minutes after smoking), we determined that cigarette smoking increased the plasma 5-HT/catecholamine concentration by several fold and the percent aggregation of platelets 2-fold. Liquid chromatography-tandem mass spectrometry analysis of proteins eluted from platelet plasma membranes of smokers and nonsmokers demonstrated that GTPase-activating proteins and proteins participating in the actin cytoskeletal network were differentially and significantly elevated in smokers' platelet membranes compared with those of nonsmokers. ...Continue Reading

References

May 1, 1976·Atherosclerosis·J P Strong, M L Richards
Nov 1, 1987·The Journal of Clinical Investigation·H C PorchetJ R Copeland
May 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L A Solberg, J P Strong
Mar 1, 1997·Journal of Toxicology and Environmental Health·D Hoffmann, I Hoffmann
Jan 15, 2000·The Journal of Biological Chemistry·I M KeulartsJ W Heemskerk
Aug 12, 2000·The Journal of Biological Chemistry·R ShirakawaT Kita
Sep 6, 2000·International Journal of Experimental Pathology·R Michael Pittilo
Jan 23, 2004·Journal of Pharmacological Sciences·Archibald McNicol, Sara J Israels
Feb 3, 2004·American Journal of Infection Control·Judith Morrison, UNKNOWN Health Canada, Nosocomial and Occupational Infections Section
Jul 20, 2005·Circulation·Majid EzzatiAlan D Lopez
Oct 1, 2005·Journal of Thrombosis and Haemostasis : JTH·D S Woulfe
May 18, 2007·Journal of Neurochemistry·B BrennerF Kilic
Jul 11, 2007·Hypertension·Guido GrassiGiuseppe Mancia
Jan 30, 2008·The Journal of Biological Chemistry·Billow A AhmedFusun Kilic
Aug 5, 2008·Trends in Pharmacological Sciences·Mark J MillanClotilde Mannoury la Cour
Nov 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Susan S SmythUNKNOWN 2008 Platelet Colloquium Participants
Jun 3, 2009·Current Vascular Pharmacology·Louisa Dowal, Robert Flaumenhaft
Jun 19, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Mingzhen LiMing-Lin Liu
Aug 24, 2010·Molecular Interventions·Charles P Mercado, Fusun Kilic
Oct 27, 2010·Molecular and Cellular Biology·Sean W WallaceAlan Hall
Feb 16, 2011·Current Opinion in Pharmacology·Charles P MercadoFusun Kilic
Apr 18, 2012·European Heart Journal·Gianfranco Parati, Murray Esler
May 23, 2012·Blood·Hans H WandallKarin M Hoffmeister
May 21, 2013·Clinical and Experimental Pharmacology & Physiology·Catherine A Martin, Barry P McGrath
Sep 3, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Holly R MiddlekauffJeffrey A Gornbein
Oct 1, 2013·Scientific Reports·Charles P MercadoFusun Kilic
Feb 28, 2014·Thrombosis and Haemostasis·S BadrnyaA Assinger
Aug 15, 2014·Blood·Yotis A SenisJun Mori
Oct 2, 2014·The Journal of Biological Chemistry·Patrick M GiguèreJoseph A Duncan
Mar 11, 2015·Hypertension·Mony Fraer, Fusun Kilic
Jan 2, 2016·International Journal of Epidemiology·Fangyi GuNeil E Caporaso
Mar 19, 2016·European Journal of Pharmacology·Kenji MatsuuraShogo Matsuyama

❮ Previous
Next ❯

Citations

Nov 10, 2018·Cell Communication and Signaling : CCS·Suryakant NitureDeepak Kumar
Jul 25, 2021·International Journal of Molecular Sciences·Omar HahadThomas Münzel

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
ELISA
Flow Cytometry
acetylation
glycosylation

Software Mentioned

Origin
MaxQuant

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

© 2022 Meta ULC. All rights reserved