Cigarette smoking, disease severity and autoantibody expression in African Americans with recent-onset rheumatoid arthritis

Annals of the Rheumatic Diseases
Ted R MikulsS Louis Bridges

Abstract

To examine the association of smoking with clinical and serological features in African Americans with recent-onset rheumatoid arthritis (RA) and to explore whether this association is dependent on the presence of the HLA-DRB1 shared epitope (SE). In African Americans with recent-onset RA (n = 300), we examined the association of cigarette smoking (current versus past versus never and pack-years of exposure) with anti-cyclic citrullinated peptide antibody, rheumatoid factor (RF) (IgM and IgA), rheumatoid nodules and baseline radiographic erosions using logistic and cumulative logistic regression (adjusting for SE status). We also examined for evidence of interaction between smoking status and SE for all outcomes. Although there was no association with RF-IgA seropositivity, current smokers were approximately twice as likely as never smokers to have higher IgA-RF concentrations (based on tertiles; OR = 1.74; 95% CI 1.05 to 2.88) and nodules (OR = 2.43; 95% CI 1.13 to 5.22). These associations were most pronounced in those with more than 20 pack-years of exposure. There was no association of smoking status or cumulative tobacco exposure with anti-cyclic citrullinated peptide antibody, IgM-RF or radiographic erosions. There was al...Continue Reading

References

Sep 1, 1992·Epidemiology·D W Hosmer, S Lemeshow
Oct 1, 1995·Annals of the Rheumatic Diseases·M HeliövaaraA Reunanen
Jul 1, 1995·Annals of the Rheumatic Diseases·T JónssonH Valdimarsson
Aug 1, 1997·Annals of the Rheumatic Diseases·K G SaagD A Schwartz
Dec 2, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T JónssonH Valdimarsson
Sep 5, 2002·Arthritis and Rheumatism·Nicola J GoodsonDeborah P M Symmons
Jan 16, 2003·Arthritis and Rheumatism·Sherine E GabrielEric L Matteson
Aug 27, 2005·European Journal of Epidemiology·Anders Ahlbom, Lars Alfredsson
Aug 27, 2005·European Journal of Epidemiology·Tomas AnderssonAnders Ahlbom
Jan 27, 2006·The New England Journal of Medicine·Christopher A HaimanLoïc Le Marchand
Feb 2, 2006·Journal of the National Cancer Institute
Jun 6, 2006·The American Journal of Medicine·Karen H CostenbaderElizabeth W Karlson
Sep 30, 2006·Arthritis and Rheumatism·Damini JawaheerLindsey A Criswell

❮ Previous
Next ❯

Citations

Dec 8, 2010·Rheumatology International·Natalí Serra-Bonett, Martín A Rodríguez
Mar 31, 2011·Rheumatology International·Yousra Ibn YacoubNajia Hajjaj-Hassouni
Aug 21, 2012·Clinical Rheumatology·Yousra Ibn YacoubNajia Hajjaj-Hassouni
Oct 5, 2011·Psychological Bulletin·Joseph W DitreMary M Meagher
Aug 24, 2011·BMC Public Health·Claudia SikorskiSteffi G Riedel-Heller
Aug 15, 2009·Arthritis Research & Therapy·Zsuzsanna BakaGyörgy Nagy
May 23, 2012·Reumatología clinica·Virginia Ruiz-Esquide, Raimon Sanmartí
Dec 23, 2015·International Journal of Rheumatic Diseases·Patompong UngprasertWonngarm Kittanamongkolchai
Dec 29, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Patompong UngprasertJohn M Davis Iii
Nov 26, 2008·Best Practice & Research. Clinical Rheumatology·Olivier VittecoqNathalie Klemmer
Aug 20, 2010·Arthritis and Rheumatism·Ted R MikulsS Louis Bridges
May 13, 2010·Arthritis Care & Research·S Louis BridgesDésirée M van der Heijde
Mar 2, 2010·Arthritis and Rheumatism·Ted R Mikuls
Apr 1, 2010·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mahmoud M AlsalahySahar M Elsayed
Jul 6, 2016·Clinical Reviews in Allergy & Immunology·Steven R Binder, Christine M Litwin
Mar 21, 2006·Journal of Autoimmunity·Danielle Mercatante CarrickPerry J Blackshear
Nov 9, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Lauren BrunierMichel De Bandt
Dec 8, 2016·European Journal of Gastroenterology & Hepatology·Sanne J H Van ErpAndrea E van der Meulen-de Jong
May 5, 2010·The Journal of Rheumatology·Leonard C Harty, Douglas J Veale
Mar 17, 2012·The Journal of Rheumatology·Mark C FisherUNKNOWN CORRONA Investigators
Nov 3, 2011·The Journal of Rheumatology·Virginia Ruiz-EsquideRaimon Sanmartí
Apr 3, 2015·The Journal of Rheumatology·Joshua F BakerTed R Mikuls
Oct 19, 2010·The Journal of Rheumatology·Theodora E MarkatseliAlexandros A Drosos
Oct 13, 2017·Rheumatology International·Mario Andrés Quintana-DuqueAntonio Iglesias-Gamarra
Oct 6, 2018·European Radiology·Matthew KoslowJay H Ryu
Dec 25, 2008·Revue des maladies respiratoires·M UndernerJ-C Meurice

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.