PMID: 11329815May 2, 2001Paper

Cigarette smoking, hypertension and erectile dysfunction

Current Medical Research and Opinion
A Ledda

Abstract

Smoking is associated with an increased risk of developing erectile dysfunction (ED). For example, in the Massachusetts Male Aging Study (MMAS), cigarette smoking amplified the risk of ED associated with other risk factors (e.g. hypertension, diabetes and dyslipidaemia) or with ageing. At the molecular level, several changes associated with smoking have been documented in man and experimental models. These changes could contribute to the pathogenesis of ED. Furthermore, studies performed in dogs demonstrated a smoking-related reduction in arterial flow and venous restriction. Similarly, impaired penile flow has been documented in men who smoke. Cigarette smoking also interferes with the effectiveness of intracavernous papaverine and PGEI. Quitting is the 'first-line' therapy of ED and one of the most important measures for the prevention of atherosclerosis.

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Citations

Jul 11, 2003·The Journal of Urology·Robert A KlonerHarin Padma-Nathan
Apr 24, 2012·Journal of Tropical Medicine·Rodrigo Gurgel-GonçalvesA Townsend Peterson
Aug 7, 2002·Current Atherosclerosis Reports·Robert A Kloner, Mark Speakman
May 10, 2002·Current Medical Research and Opinion·M A KhanUNKNOWN Consensus Writing Committee
May 2, 2001·Current Medical Research and Opinion·A Ledda
Jul 4, 2012·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chih-Kuang LiuMing-Chung Ko
Jan 31, 2006·Pharmacology & Therapeutics·Giuseppe CirinoVincenzo Mirone
May 23, 2002·Current Medical Research and Opinion·Masood A KhanDimitri P Mikhailidis
Oct 21, 2003·Angiology·Stavroula TsiaraDimitri P Mikhailidis
Apr 23, 2004·International Journal of Impotence Research·J E ToblliF Inserra
Oct 21, 2006·Current Opinion in Urology·Alexander Müller, John P Mulhall
Mar 14, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Zhengyuan ChenZhaoyun Zhang

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