PMID: 8601881Mar 1, 1996Paper

Cigarette smoking increases the development of initial hyperplasia after vascular injury

Journal of Vascular Surgery
M M LawW J Quiñones-Baldrich

Abstract

Our purpose was to determine whether exposure to cigarette smoke increases the development of intimal hyperplasia (IH) after vascular injury. Sixteen adult male Sprague-Dawley rats underwent standardized balloon catheter injury of the left common carotid artery. For 4 weeks before and 4 weeks after injury, animals in the experimental group (n=8) were exposed to cigarette smoke with an automated vacuum pump device. Animals in the control group (n=8) were restrained in the smoking device for an identical amount of time and underwent arterial injury at 4 vivo, prepared as histologic cross sections, and stained for elastin. IH was measured by planimetry and is reported both as the absolute area of IH and as the ratio (IH/IEL) of the absolute area of IH to the normalized area enclosed by the internal elastic lamina (expressed as a percent). The absolute area of IH was 2.09 +/- 0.34 for the experimental group compared with 0.94 +/- 0.25 for the control group; mean IH/IEL was 43% +/- 7.1% for the experimental group versus 17.7% +/- 4.7% for the control group (p < 0.05, two tailed unpaired t test. Inhalation of cigarette smoke increases the development of intimal hyperplasia in a rat model of a balloon catheter arterial injury.

References

Apr 1, 1978·The British Journal of Surgery·K A MyersP J Morris
Jan 1, 1990·Catheterization and Cardiovascular Diagnosis·R R AroraJ Hollman
Apr 1, 1990·Journal of Vascular Surgery·M A GoldenA W Clowes
Dec 1, 1986·British Journal of Haematology·N BlaesM Ricetti
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·E CsonkaH Jellinek
Oct 1, 1973·Postgraduate Medical Journal·P Astrup
Dec 1, 1984·British Journal of Haematology·R M PittiloN Woolf
Jan 1, 1980·British Journal of Pharmacology·T Sonnenfeld, A Wennmalm
Jul 1, 1981·Thrombosis Research·F M BooyseJ Radek
Jan 1, 1993·International Journal of Cardiology·D BenchimolH Bricaud

❮ Previous
Next ❯

Citations

Aug 18, 2004·The Journal of Surgical Research·Joseph A DavisMohammed M Moursi
Mar 9, 1999·The Journal of Surgical Research·R SarkarA S Santibanez-Gallerani
Nov 11, 1998·Journal of Vascular Surgery·F N SouthernM M Moursi
Dec 20, 2000·The Journal of Surgical Research·B S ConklinC Chen
Jul 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Takeo AnazawaBojan Cercek
Mar 17, 2007·Current Hypertension Reports·Carlos Mercado, Edgar A Jaimes
Mar 18, 2005·Anatomia, histologia, embryologia·N SolanesM Heras
Aug 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michiaki MatsumotoBojan Cercek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.