Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor.

FEBS Letters
Wei-Chun HuangFuSerge Y Fuchs

Abstract

While negative effect of smoking on the resistance to viral infections was known, the underlying mechanisms remained unclear. Here we report that products of cigarette smoking compromise the cellular anti-viral defenses by inhibiting the signaling induced by Type I interferon (IFN). Cigarette smoking condensate (but not pure nicotine) stimulated specific serine phosphorylation-dependent ubiquitination and degradation of the IFNAR1 subunit of the Type I IFN receptor leading to attenuation of IFN signaling and decreased resistance to viral infection. This resistance was restored in cells where phosphorylation-dependent degradation of IFNAR1 is abolished. We conclude that smoking compromises cellular anti-viral defenses via degradation of Type I IFN receptor and discuss the significance of this mechanism for efficacy of IFN-based therapies.

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Citations

Mar 21, 2012·Immunology and Cell Biology·Niamh E Mangan, Ka Yee Fung
Dec 2, 2009·The Journal of Biological Chemistry·Sabyasachi BhattacharyaSerge Y Fuchs
Nov 3, 2009·American Journal of Respiratory Cell and Molecular Biology·Ilona JaspersTerry L Noah
Mar 1, 2012·American Journal of Respiratory Cell and Molecular Biology·Gayathriy BalamayooranSamithamby Jeyaseelan
May 28, 2010·Respiratory Research·Modestos A ModestouDwight C Look
Dec 24, 2013·American Journal of Respiratory Cell and Molecular Biology·Andrea C SchambergerOliver Eickelberg
Aug 21, 2013·Journal of Cellular Biochemistry·Christopher J Carbone, Serge Y Fuchs
Mar 10, 2009·Toxicology and Applied Pharmacology·Navneet K DhillonAmy O'Brien-Ladner
Apr 7, 2018·Expert Opinion on Biological Therapy·Laura DumitrescuRadu Tanasescu
Jun 12, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elizabeth M MartinIlona Jaspers
Jun 1, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Li ZuoThomas M Best
Feb 5, 2021·Frontiers in Medicine·Francesca Polverino, Farrah Kheradmand
Mar 12, 2021·Human Vaccines & Immunotherapeutics·Simin WenYuelong Shu
Jun 1, 2021·Frontiers in Pediatrics·Esha BrarXin Li
Nov 3, 2021·Lupus Science & Medicine·Warren David RaymondJohannes Cornelis Nossent

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