Abstract
Aging and smoking are known to promote atrophic gastritis (AG) and intestinal metaplasia (IM). This study investigated the relationship between Helicobacter pylori (Hp) infection, aging, smoking, and AG/IM. Ninety-six Hp-negative and 231 Hp-positive subjects were divided according to age; (< or = 39 years, 40-59 years, and > or = 60 years) and smoking history (never smoked, or currently smoking). Histologic grading was performed according to the updated Sydney system. Fasting pH, total bile acid (TBA) concentration, and ammonia (NH3) concentration in gastric juice were measured. Comparisons were made based on Hp status, age, and smoking. Independent relative risks for severe AG and IM were calculated. Grades of atrophy and IM were significantly higher in Hp-positive subjects, and these increased with age. Within Hp-positive subjects, grades of atrophy and IM were higher in smokers and in the middle and upper age groups. Within Hp-positive subjects, gastric pH and TBA were similarly higher in smokers and older subjects. An increased risk of severe AG/IM was statistically associated with smoking (OR 9.31, 3.85-22.50/OR 4.91, 1.90-12.68) and high TBA concentrations (OR 2.92, 1.19-7.17/OR 3.28, 1.25-8.62). Both Hp infection and agi...Continue Reading
Citations
Aug 17, 2002·Alimentary Pharmacology & Therapeutics·M ItoK Chayama
Jun 18, 2004·European Journal of Gastroenterology & Hepatology·Itaru OhyamaHidemi Goto
Oct 27, 2007·Arquivos De Gastroenterologia·Leandro Bizarro MullerAlexandre Rampazzo
Jan 13, 2015·Helicobacter·Tomoari KamadaDavid Y Graham
Apr 4, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·A Bleich, M Mahler
Aug 2, 2006·Cancer Science·Nobuyuki HamajimaYasuyuki Goto
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Tarmo T KoivistoMartti A Färkkilä
Jul 25, 2009·European Journal of Epidemiology·Anne Mette AsfeldtEyvind J Paulssen
May 27, 2010·International Journal of Cancer. Journal International Du Cancer·Mariam Abdullahi AdamuHermann Brenner
Mar 31, 2011·Digestive Diseases and Sciences·Shunsuke YamamotoYuji Matsuzawa
May 10, 2019·PloS One·Muhammad MiftahussururYoshio Yamaoka
Aug 29, 2002·Helicobacter·Alberto Pilotto, Nathalie Salles
Apr 27, 2004·Journal of Pharmacological Sciences·William K K Wu, Chi Hin Cho
May 20, 2008·International Journal of Cancer. Journal International Du Cancer·Melanie N Weck, Hermann Brenner
Feb 24, 2010·International Journal of Cancer. Journal International Du Cancer·Carlos A GonzálezJosé Miguel Sanz-Anquela
Sep 5, 2007·Alimentary Pharmacology & Therapeutics·M N WeckH Brenner
Aug 22, 2009·Journal of Human Genetics·Masayuki TatemichiShoichiro Tsugane
Jan 18, 2020·Expert Review of Gastroenterology & Hepatology·Bruno AnnibaleEdith Lahner
Jan 5, 2005·Digestive Diseases and Sciences·Yaron NivRivka Koren
Dec 16, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Gareth A O ThomasJohn R Ingram
Jun 17, 2020·International Journal of Cancer. Journal International Du Cancer·Mounia El KhadirBahia Bennani
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eiji Nakamura, Susan J Hagen
Dec 13, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Manami InoueUNKNOWN JPHC Study Group
Feb 2, 2021·Curēus·Anisha GargBhaumik Brahmbhatt
Dec 14, 2005·Current Problems in Surgery·Bruce E StabileDavid L Weeks
Feb 24, 2006·The American Journal of Medicine·Takeshi SuzukiKazuo Tajima
Oct 30, 2020·Journal of Clinical Gastroenterology·Xianzhu ZhouYiqi Du
Dec 19, 2020·Journal of Clinical Gastroenterology·Aaron P ThriftHashem B El-Serag