PMID: 2500582Jul 17, 1989Paper

Ciguatera and mannitol: experience with a new treatment regimen

The Medical Journal of Australia
J H PearnN C Gillespie

Abstract

Ciguatera is a distressing, hitherto-untreatable and not rare disease which results from the eating of ciguatoxin-contaminated fish from tropical and subtropical waters. We report here the results of a pilot study to assess the efficacy of mannitol therapy in ciguatera poisoning. Twelve adult patients (six men) have been treated, five of whom--who were ill acutely--experienced a significant benefit from this therapy, in three cases, with a hitherto-unexperienced dramatic reversal of symptoms. We conclude that an intravenous infusion of 1.0 g/kg of mannitol which is given over 45 minutes, after rehydration if required, can be of significant benefit to at least some acutely intoxicated victims. We postulate either a reduction of axonal oedema, or a scavenger effect, or both, as the mechanism of the beneficial effects of mannitol. Ciguatoxin is rich in hydroxyl groups, and causes microscopic oedema of neural tissue. If our conclusion of the beneficial effects of mannitol therapy is confirmed, this will offer the first effective therapy for acute phases of this disease, and has promise of preventing much long-term morbidity.

References

Nov 1, 1979·The American Journal of Tropical Medicine and Hygiene·R BagnisS Laugier
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·E BenoitJ M Dubois
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R J Lewis, R Endean
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·R J Lewis
Jul 3, 1986·The New England Journal of Medicine·P M HoogerbruggeA T vd Ploeg
Jun 1, 1988·The American Journal of Medicine·W R LangeJ Hobbs

❮ Previous
Next ❯

Citations

Jan 1, 1992·Journal of the Neurological Sciences·N Senanayake, G C Román
Aug 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·R J LewisD C McGiffin
Apr 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·R J Lewis, A W Hoy
Aug 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·R J LewisM Sellin
Aug 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·P Glaziou, A M Legrand
May 1, 1995·Clinical Neurology and Neurosurgery·M R Watters
Nov 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R J Lewis, M J Holmes
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·R J Lewis
Jan 27, 1999·Toxicon : Official Journal of the International Society on Toxinology·C E PurcellJ Cameron
Dec 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·J Pearn
May 15, 2013·Singapore Medical Journal·Thomas Yan Keung Chan
Nov 14, 2008·Marine Drugs·Melissa A FriedmanAndrew Reich
Oct 19, 1992·The Medical Journal of Australia·R M BerlinD G Blythe
Nov 26, 2010·Annals of Tropical Medicine and Parasitology·I StewartS B Craig
Oct 8, 2013·Neurotoxicity Research·N BraidyG J Guillemin
Jul 27, 2001·Journal of Travel Medicine·M BavastrelliS Sanguigni
Jan 1, 1993·Journal of Toxicology. Clinical Toxicology·A E Swift, T R Swift
Feb 25, 2000·Therapeutic Drug Monitoring·R J Lewis
Apr 20, 2000·The Medical Journal of Australia·L Lehane
May 26, 1998·Australian and New Zealand Journal of Public Health·J Y TingJ H Pearn
Dec 1, 2001·Human & Experimental Toxicology·T Y Chan, T C Kwok
May 24, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Michael E Mullins, Robert S Hoffman
Feb 3, 2011·Phytotherapy Research : PTR·Shilpa Kumar-RoinéDominique Laurent
Sep 3, 1990·The Medical Journal of Australia·J Williamson
Jan 12, 2002·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·J Y Ting, A F Brown
Jan 19, 2021·Journal of General and Family Medicine·Takashi WatariYu Amano
Dec 4, 1989·The Medical Journal of Australia·J Pearn
Mar 17, 1997·The Medical Journal of Australia·J H Pearn
May 5, 1997·The Medical Journal of Australia·P J FennerM L Williams
Nov 15, 2000·International Journal of Food Microbiology·L Lehane, R J Lewis
Mar 16, 2005·Revista clínica española·S Puente PuenteJ M González-Lahoz
Mar 22, 2005·Lancet Neurology·Geoffrey K Isbister, Matthew C Kiernan
Sep 17, 2005·Toxicon : Official Journal of the International Society on Toxinology·Raphaële Boydron-Le GarrecDominique Laurent
Feb 1, 1997·Emergency Medicine Clinics of North America·D MinesS M Shepherd
Aug 26, 2006·Toxicon : Official Journal of the International Society on Toxinology·Richard J Lewis
May 8, 2007·Emergency Medicine Clinics of North America·David T LawrenceChristopher P Holstege
Sep 29, 2009·Toxicon : Official Journal of the International Society on Toxinology·Robert W Dickey, Steven M Plakas
Jan 5, 2002·Wilderness & Environmental Medicine·D J Farstad, T Chow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicon : Official Journal of the International Society on Toxinology
R J LewisD C McGiffin
© 2022 Meta ULC. All rights reserved