PMID: 9177239Jun 10, 1997Paper

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

Proceedings of the National Academy of Sciences of the United States of America
I GloaguenR Laufer

Abstract

Receptor subunits for the neurocytokine ciliary neurotrophic factor (CNTF) share sequence similarity with the receptor for leptin, an adipocyte-derived cytokine involved in body weight homeostasis. We report here that CNTF and leptin activate a similar pattern of STAT factors in neuronal cells, and that mRNAs for CNTF receptor subunits, similarly to the mRNA of leptin receptor, are localized in mouse hypothalamic nuclei involved in the regulation of energy balance. Systemic administration of CNTF or leptin led to rapid induction of the tis-11 primary response gene in the arcuate nucleus, suggesting that both cytokines can signal to hypothalamic satiety centers. Consistent with this idea, CNTF treatment of ob/ob mice, which lack functional leptin, was found to reduce the adiposity, hyperphagia, and hyperinsulinemia associated with leptin deficiency. Unlike leptin, CNTF also reduced obesity-related phenotypes in db/db mice, which lack functional leptin receptor, and in mice with diet-induced obesity, which are partially resistant to the actions of leptin. The identification of a cytokine-mediated anti-obesity mechanism that acts independently of the leptin system may help to develop strategies for the treatment of obesity associa...Continue Reading

References

Mar 1, 1990·Brain Research. Developmental Brain Research·H J LeeB H Wainer
Aug 1, 1972·Physiology & Behavior·A I LeshnerR L Squibb
Apr 1, 1967·Diabetologia·D L Coleman, K P Hummel
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell
Jul 28, 1995·Science·M A PelleymounterF Collins
Feb 1, 1994·Annals of Neurology·F DittrichM Sendtner
Jun 1, 1994·The Journal of Clinical Investigation·J T HendersonJ C Roder
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L ShapiroC A Dinarello
May 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A K Johnson, P M Gross
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Dec 29, 1995·Cell·L A TartagliaR I Tepper
May 1, 1996·The Journal of Clinical Investigation·C GrunfeldK R Feingold
Feb 15, 1996·Nature·G H LeeJ M Friedman
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·N LevinF de Sauvage
Jun 27, 1996·Nature·A J Woods, M J Stock
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·N GhilardiR C Skoda
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·H BaumannL A Tartaglia
Sep 1, 1996·The Journal of Clinical Investigation·M W SchwartzD G Baskin
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Di MarcoR Laufer
Jan 1, 1996·Annual Review of Neuroscience·N Y Ip, G D Yancopoulos
Mar 1, 1996·Brain Research. Molecular Brain Research·J F Poduslo, G L Curran

❮ Previous
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Citations

Jan 23, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Vance B Matthews, Mark A Febbraio
May 17, 2000·Pharmaceutica acta Helvetiae·M W SleemanS J Wiegand
Apr 24, 2001·Pharmacology & Therapeutics·J C ClaphamM Tadayyon
May 8, 2001·Trends in Pharmacological Sciences·M ChiesiK G Hofbauer
Oct 24, 1998·Domestic Animal Endocrinology·R W Johnson
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·John-Olov JanssonVille Wallenius
Aug 26, 2000·Current Opinion in Chemical Biology·L H Van der Ploeg
Apr 28, 2001·Trends in Molecular Medicine·R S Ahima, S Y Osei
Sep 21, 2000·The Proceedings of the Nutrition Society·G A Bray
Sep 8, 2012·The Proceedings of the Nutrition Society·Lynda M Williams
May 6, 2006·Nature Medicine·Rexford S Ahima
Apr 11, 2006·Nature Medicine·Matthew J WattGregory R Steinberg
Apr 10, 1999·Clinical Endocrinology·C S Mantzoros, S J Moschos
Feb 28, 2001·Diabetes, Obesity & Metabolism·J M Bryson
Jun 20, 2008·The Journal of Biological Chemistry·Ursula A WhiteJacqueline M Stephens
May 10, 2005·The Proceedings of the Nutrition Society·Jonathan R S Arch
Sep 14, 2007·International Journal of Clinical Practice·R P Vincent, C W le Roux
Sep 8, 2007·Neuroendocrinology·Jessica B Buchanan, Rodney W Johnson
Apr 4, 2007·The Journal of Clinical Investigation·Mark A Febbraio
Jan 21, 2012·The Review of Diabetic Studies : RDS·Hannah C GreenwoodKevin G Murphy
Apr 4, 2002·Drugs·José-Antonio Fernández-LópezMarià Alemany
Jan 2, 2003·Journal of Endocrinological Investigation·R VettorG Federspil
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·L R CarpenterN Stahl
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·P D LambertS J Wiegand
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·S P Kalra
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shubha V Y RajuJoshua M Hare
Nov 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·M W SleemanS J Wiegand
Feb 18, 2015·Biology·Carrie M Elks, Jacqueline M Stephens
Apr 19, 2005·Expert Opinion on Investigational Drugs·Tung M Fong
Oct 2, 2003·Expert Opinion on Biological Therapy·Kristina WalleniusVille Wallenius
Apr 19, 2005·Expert Opinion on Biological Therapy·Sergei Zolotukhin
Jul 25, 2006·Expert Opinion on Investigational Drugs·Marcio C Mancini, Alfredo Halpern
Jan 29, 2016·Cytokine·Sarah PasquinJean-François Gauchat

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