PMID: 15220205Jun 29, 2004Paper

Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats

Diabetes
Andrew P MizisinNigel A Calcutt

Abstract

Ciliary neurotrophic factor (CNTF) protein and bioactivity are reduced in the peripheral nerve of hyperglycemic rats with a cause related to metabolism of hexose sugars by aldose reductase. Here the efficacy of CNTF treatment against disorders of nerve function in hyperglycemic rats was investigated. CNTF treatment from the onset of 8 weeks of galactose feeding prevented nerve conduction slowing in a dose-dependent manner. Streptozotocin-induced diabetic rats were maintained for 4 weeks before CNTF treatment was initiated. Four weeks of CNTF treatment significantly improved nerve conduction compared with untreated diabetic rats and also normalized the recovery of toe spread after sciatic nerve crush. One week of CNTF treatment significantly improved the distance of sensory nerve regeneration achieved after nerve crush injury compared with untreated diabetic rats. CNTF was without effects on any parameter in nondiabetic rats. Eight weeks of diabetes did not impair macrophage recruitment 1 and 7 days after nerve crush; neither did intraneural injections of CNTF and CNTFRalpha enhance recruitment in diabetic or control rats. These observations point to the potential utility of CNTF in treating nerve dysfunction in experimental dia...Continue Reading

References

Dec 1, 1975·Diabetes·R E SchmidtD B McDougal
Oct 1, 1992·Current Opinion in Neurobiology·V H Perry, M C Brown
Jan 1, 1992·Pharmacology & Therapeutics·D R TomlinsonA L Carrington
Nov 1, 1989·Journal of the Neurological Sciences·A R Ekström, D R Tomlinson
Aug 1, 1980·The Journal of Clinical Investigation·J Jakobsen, P Sidenius
Aug 29, 1994·Brain Research·Z SahenkJ R Mendell
Apr 1, 1996·Archives of Otolaryngology--head & Neck Surgery·J P NewmanD J Terris
Mar 1, 1997·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·A MiyauchiL B Dahlin
Mar 1, 1997·Acta Neuropathologica·H S Taskinen, M Röyttä
Dec 31, 1997·Journal of Neuropathology and Experimental Neurology·A P MizisinN A Calcutt
Aug 26, 1998·The Biochemical Journal·P C HeinrichL Graeve
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L R WilliamsS Varon

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Citations

Aug 6, 2008·Histochemistry and Cell Biology·Kazunori SangoHitoshi Kawano
Nov 8, 2008·Current Diabetes Reports·Marina MataDavid J Fink
Sep 30, 2009·Neuroreport·Hiroaki NakamuraTomihisa Yokoyama
Aug 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Yuanlin Piao, Xiaochun Liang
Feb 10, 2010·Journal of Neuropathology and Experimental Neurology·Yuk Shan ChenSookja K Chung
Aug 15, 2009·Journal of Neuropathology and Experimental Neurology·Nigel A CalcuttPeter W Stacpoole
Jul 4, 2008·Journal of Neuropathology and Experimental Neurology·Corinne G JolivaltNigel A Calcutt
Mar 27, 2012·Neurobiology of Disease·Subir K Roy ChowdhuryPaul Fernyhough
Jul 12, 2008·Pharmacology & Therapeutics·James L EdwardsEva L Feldman
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Nov 18, 2008·Journal of Neurochemistry·Hyun Kyoung LeeHwan Tae Park
Oct 16, 2008·Medicinal Research Reviews·Michael L MohlerDuane D Miller
Jul 3, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Norma Hernández-PedroOscar Arrieta
May 14, 2011·Acta histochemica·Claudia M Toledo-Corral, Lisa R Banner
Jan 31, 2017·Nature Reviews. Neurology·Nádia P GonçalvesTroels S Jensen
Jan 18, 2017·The Journal of Clinical Investigation·Nigel A CalcuttPaul Fernyhough
Jun 25, 2017·Experimental Neurology·Jon P NiemiRichard E Zigmond
Feb 14, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·John GardinerRobyn Overall
Nov 23, 2006·Journal of the Peripheral Nervous System : JPNS·Yun JiangAndrew P Mizisin
Jul 7, 2017·The International Journal of Lower Extremity Wounds·Siamak NajiRahim Mohammadi
Apr 27, 2019·Frontiers in Cellular Neuroscience·Arul DuraikannuDouglas W Zochodne
Aug 13, 2021·Biochemistry and Biophysics Reports·Fathia Abd Elwahid MannaaNevein Naim Fadl
Jul 6, 2019·ACS Chemical Neuroscience·Shadi HoushyarRobert Shanks

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