Ciliary neurotrophic factor preferentially enhances spontaneous IgE production by B cells from atopic patients

Neuropeptides
H Kimata

Abstract

The effect of ciliary neurotrophic factor (CNTF) on IgE production by purified B cells from atopic patients was studied. CNTF significantly enhanced spontaneous IgE production by B cells from patients with atopic eczema/dermatitis syndrome (AEDS) in a dose-dependent fashion, and maximum enhancement was achieved at 1 ng/ml. CNTF-induced enhancement of IgE production was blocked by anti-CNTF mAb or anti-gp 130 mAb, but not by anti-IL-6 mAb. On the other hand, CNTF did not significantly enhance spontaneous production of IgGl, IgG2, IgG3, IgG4, IgM, IgAl or IgA2 by B cells from AEDS patients. In contrast to B cells from AEDS patients, B cells from non-atopic subjects failed to produce IgE spontaneously, and CNTF did not induce IgE production by non-atopic subjects' B cells. B cells from atopic patients contained surface IgE positive B cells (sIgE+ B cells), which spontaneously produced IgE, while surface IgE negative B cells (sIgE- B cells) failed to do so. CNTF enhanced IgE production by sIgE+ B cells from patients with AEDS, allergic rhinitis or bronchial asthma, while CNTF failed to induce IgE from sIgE- B cells from these patients. Stimulation of sIgE- B cells with IL-4 plus anti-CD40 mAb induced IgE production. However, stimul...Continue Reading

References

Apr 1, 1990·The American Journal of Medicine·M BoguniewiczD Y Leung
Nov 1, 1994·Journal of Neurobiology·M SendtnerH Thoenen
Mar 1, 1995·The Journal of Allergy and Clinical Immunology·H Kimata
May 8, 1999·British Journal of Haematology·A WierzbowskaT Robak

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Citations

Aug 9, 2011·Current Opinion in Allergy and Clinical Immunology·Brett P Bielory, Terrence P O'Brien
Jun 27, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·José Miguel Lloris-CarsíDolores Cejalvo-Lapeña
Sep 22, 2017·American Journal of Respiratory Cell and Molecular Biology·Akul SinghaniaTimothy S C Hinks

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