Ciliated adenocarcinomas of the lung: a tumor of non-terminal respiratory unit origin

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Won Young ParkMee Young Sol

Abstract

Whereas most carcinomas occur through a sequential step, atypical adenomatous hyperplasia and bronchioloalveolar carcinoma pathway is known for pulmonary adenocarcinoma. This type is known as terminal respiratory unit adenocarcinoma. Based on our observation of transitions from normal ciliated columnar cells to adenocarcinoma via dysplastic mucous columnar cells, we reviewed our archive of pulmonary adenocarcinoma. Terminal respiratory unit type adenocarcinoma was defined as adenocarcinoma with type II pneumocyte, Clara cell, or bronchiolar cell morphology according to previous reports. Among 157 cases, 121 cases have been identified as terminal respiratory unit type adenocarcinoma and 36 cases as non-terminal respiratory unit type adenocarcinoma. Among non-terminal respiratory unit type adenocarcinoma, 24 cases revealed mucous columnar cell changes that were continuous with bronchial ciliated columnar cells. The mucous columnar cells became dysplastic showing loss of cilia, disorientation, and enlarged nuclei. Adenocarcinoma arose from these dysplastic mucous columnar cells and, characteristically, this type of adenocarcinoma showed acute inflammation, and honeycombing changes in the background. TTF1 immunostaining was consist...Continue Reading

References

Feb 1, 1987·Journal of Clinical Pathology·C W Edwards
Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·S M Jensen-TaubmanR I Linnoila
Aug 17, 2000·British Journal of Cancer·A D Chapman, K M Kerr
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M MoriA E Fraire
May 23, 2002·The American Journal of Surgical Pathology·Yasushi YatabeTakashi Takahashi
Apr 10, 2003·Virchows Archiv : an International Journal of Pathology·Reinhard UllmannHelmut H Popper
Mar 30, 2004·Journal of Clinical Pathology·G StenhouseK M Kerr
Apr 16, 2005·The American Journal of Surgical Pathology·Yasushi YatabeTetsuya Mitsudomi
May 12, 2007·Pathology International·Yasushi Yatabe, Tetsuya Mitsudomi
May 29, 2007·The American Journal of Surgical Pathology·Sylvie LantuejoulGiulio Rossi
Feb 4, 2009·Histopathology·Keith M Kerr

❮ Previous
Next ❯

Citations

Jan 12, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shuji OginoEdward Giovannucci
Apr 15, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shinji SumiyoshiHironori Haga
Aug 28, 2015·Expert Review of Respiratory Medicine·Anna TruiniGiulio Rossi
Jan 18, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Luisella RighiMauro Papotti
Sep 30, 2014·Cell·Randall J PlattFeng Zhang
Apr 14, 2016·Biochemical and Biophysical Research Communications·Cécile DauGerald S Braun
Nov 12, 2014·Annual Review of Physiology·Ann E TilleyRonald G Crystal
Aug 31, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kyohei MasaiHisao Asamura
Oct 13, 2015·The American Journal of Surgical Pathology·Justin A Bishop, William H Westra
Oct 20, 2018·Head and Neck Pathology·Pooja NavaleMary Beth Beasley
Dec 20, 2020·Journal of Internal Medicine·J Sainz de AjaC F Kim
May 15, 2021·Seminars in Diagnostic Pathology·Tzu-Hang Kao, Yi-Chen Yeh
Sep 28, 2021·Interactive Cardiovascular and Thoracic Surgery·Dae Hyeon KimYoung Tae Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.