Ciliostasis of airway epithelial cells facilitates influenza A virus infection

Veterinary Research
Yuguang FuGeorg Herrler

Abstract

Porcine precision-cut lung slices (PCLS) were used to analyze the effect of the ciliary activity on infection of airway epithelial cells by influenza viruses. Treatment of slices with 2% NaCl for 30 min resulted in reversible ciliostasis. When PCLS were infected by a swine influenza virus of the H3N2 subtype under ciliostatic conditions, the viral yield was about twofold or threefold higher at 24 or 48 h post-infection, respectively, as compared to slices with ciliary activity. Therefore, the cilia beating not only transports the mucus out of the airways, it also impedes virus infection.

References

Mar 25, 1999·The Laryngoscope·W M BoekE H Huizing
Jan 26, 2007·Veterinary Research Communications·J VietmeierM Kietzmann
Mar 26, 2014·Tissue Barriers·Shyamala GanesanUma S Sajjan
Nov 12, 2014·Annual Review of Physiology·Ann E TilleyRonald G Crystal

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Citations

Aug 14, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Li Eon Kuek, Robert J Lee
Nov 24, 2020·Annals of Clinical Microbiology and Antimicrobials·Carmen Amelia Molina-TorresPilar Carranza-Rosales
Mar 28, 2021·European Journal of Clinical Pharmacology·Suzy HuijghebaertGuido Vanham

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Methods Mentioned

BETA
salt treatment

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