Abstract
Male infertility prevalence is higher in diabetic patients. Those patients exhibit testicular oxidative damage due to sustained hyperglycemia and inflammation. The study has investigated the efficacy of cilostazol, a phosphodiesterase 3 inhibitor, on testicular damage of diabetic rats. Streptozotocin-induced diabetes in rats was used as a model. Six control male rats and 24 diabetic male rats were divided into the following: diabetic, cilostazol at low dose, cilostazol at high dose, and sildenafil treated rat groups. Treatment period was 4 weeks. Then, serum testosterone, testicular oxidative parameters, and testicular oxidant defenses were assayed. Real time PCR was done for quantification of Phosphoinositide 3-kinase (PI3K), Akt, and nuclear factor (NF)-κB mRNA. Expression of testicular inducible nitric oxide synthase (iNOS) was assessed. Diabetes negatively affected the testicular tissue as evident by biochemical analysis and histopathology. Four weeks of cilostazol or sildenafil treatment improved anti-oxidative capacity, ameliorated lipid peroxidation and the pro-inflammatory iNOS expression in testicular tissue. Testosterone level and the spermatogenesis showed marked improvement. Quantitative mRNA expression showed an el...Continue Reading
Citations
Feb 7, 2019·The Journal of Toxicological Sciences·Qingshu LiLi Yuan
Nov 7, 2019·Environmental Toxicology·Yin ChengMinyou Qi
Nov 30, 2019·Nephrology·Yan QuCuiping Li
Apr 2, 2020·Human & Experimental Toxicology·M Z MohamedA M Abdel-Aziz
May 28, 2020·Toxicology Mechanisms and Methods·Asmaa Mohamed Abdel-AzizMaha Yehia Kamel
Mar 23, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Heba M HafezHanaa Hassanein
Sep 5, 2018·Current Clinical Pharmacology·Marwa HassanHend M Abd Elghany
Dec 12, 2018·Human & Experimental Toxicology·M Z MohamedM A Ibrahim
Jun 10, 2020·Pharmacological Reports : PR·Asmaa Mohamed Abdel-AzizHanaa Mohamed Khalaf
May 20, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Asmaa Mohamed Abdel-AzizSeham A Abdel-Gaber
Sep 18, 2020·Biology of the Cell·Yuan TianFa Sun
Nov 5, 2019·Chemico-biological Interactions·Ya-Ping JiangJian-Qiang Yu
Jan 29, 2021·3 Biotech·Abbirami ElangovanSivasudha Thilagar
Oct 16, 2020·Environmental Toxicology·Ling-Ling ZhaoOpeyemi Joshua Olatunji
Nov 30, 2020·European Journal of Pharmacology·Khaled BenchoulaWong Eng Hwa