Cilostazol research in Asia: can it be applied to European and American patients?

International Journal of Stroke : Official Journal of the International Stroke Society
Jong S KimShinichiro Uchiyama

Abstract

Cilostazol is an antiplatelet drug often used in Asian countries like Korea, Japan, and China. However, it is rarely used in the west. Cilostazol inhibits phosphodiesterase, increases cyclic AMP concentrations, and consequently inhibits platelet aggregation. Interestingly, it also has vasodilatory activity, inhibits vascular smooth muscle proliferation, and protects the endothelium. Studies in Asia have shown that cilostazol is effective in the secondary prevention of stroke. Moreover, it is significantly less likely to cause bleeding complications than aspirin. Additional trials have shown that cilostazol is effective in the prevention of intracranial atherosclerosis progression. Unfortunately, cilostazol has rarely been studied in non-Asian stroke patients and, accordingly, the benefits of cilostazol are less well appreciated in Europe and America than in Asia. Although further studies are required, we suggest that at least some stroke patients (e.g., patients prone to bleeding, patients with intracranial atherosclerosis, etc.) may readily benefit from cilostazol regardless of ethnicity.

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Apr 18, 2018·Journal of Alzheimer's Disease : JAD·Mi-Young KimYi-Sook Jung
Aug 15, 2017·Parasitology·Rebecca L CharltonPatrick G Steel
May 23, 2017·Psychological Medicine·M A Di BiaseA Zalesky
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Oct 15, 2019·Stroke; a Journal of Cerebral Circulation·Seung Min KimSun U Kwon
Feb 6, 2021·Stroke and Vascular Neurology·Choon Han TanBenjamin Yq Tan
Sep 15, 2021·Stroke; a Journal of Cerebral Circulation·Adam de HavenonMaarten G Lansberg

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