Cilostazol versus aspirin therapy in patients with chronic dizziness after ischemic stroke

Clinical Neurology and Neurosurgery
Ken JohkuraYoshiyuki Kuroiwa

Abstract

Chronic dizziness is frequently reported by patients in the chronic stage after ischemic stroke. The aim of this study was to determine the efficacy of cilostazol versus that of aspirin for the chronic dizziness that follows ischemic stroke. We performed a prospective, randomized, open-label, blinded endpoint trial. One hundred six patients who suffered supratentorial ischemic stroke within the previous 1-6 months and subsequently complained of persistent dizziness without other obvious sequelae were enrolled. Patients were randomly given cilostazol (200mg/day) or aspirin (100mg/day) for 6 months. Rates of improvement in the dizziness were then evaluated. Changes in fixation suppression of the vestibulo-ocular reflex (an indicator of cerebral control over the brainstem reflex related to balance), regional cerebral blood flow (CBF) in the cerebrum, cerebellum, and brainstem; and the Zung Self-Rating Depression Scale (SDS) were also evaluated. Dizziness was significantly improved in the cilostazol group versus the aspirin group (P<0.0001) after the 6-month therapy. The capacity for fixation suppression of the vestibulo-ocular reflex was improved (P<0.0001), and regional CBF in the cerebrum (relative to that in the brainstem [P=0....Continue Reading

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Citations

Jul 31, 2013·Clinical Neurology and Neurosurgery·Bin Liu, Zerui Zhuang
Dec 22, 2014·Journal of the Neurological Sciences·Ken JohkuraKazuo Funabiki
Aug 20, 2016·Journal of the Neurological Sciences·Kazumitsu AmariKen Johkura
Jul 11, 2020·Stroke; a Journal of Cerebral Circulation·Caroline McHutchisonJoanna M Wardlaw
Feb 6, 2021·Stroke and Vascular Neurology·Choon Han TanBenjamin Yq Tan

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