PMID: 3757941Sep 1, 1986Paper

Cimetidine and carbamazepine: a complex drug interaction

Epilepsia
M J DaltonJ Clark

Abstract

Cimetidine has been shown to inhibit the elimination of carbamazepine after a single oral dose. The mechanism of this interaction is thought to be inhibition of carbamazepine metabolism by the hepatic microsomal enzyme system. Because carbamazepine metabolism undergoes autoinduction with chronic administration, it is not known whether or not the clinical significance of this interaction can be predicted from the results of a single-dose study. The purpose of this study was to evaluate the presence of an interaction under steady-state enzyme-induced conditions. Using an open treatment design, carbamazepine, 300 mg b.i.d., was taken by eight healthy volunteers for 42 days (days 1-42). Cimetidine, 400 mg t.i.d., was taken for 7 days (days 29-35). Steady-state carbamazepine increased 17% after 2 days of cimetidine treatment (from 4.7 +/- 0.8 to 5.5 +/- 1.4 micrograms/ml; p less than 0.05). Six of the eight subjects noted side effects shortly after starting cimetidine treatment. Carbamazepine returned to the pre-cimetidine level and the side effects diminished by the 7th day of cimetidine administration. Therefore, the clinical significance of this interaction appears to be time dependent, and could not be predicted from the results...Continue Reading

References

Mar 1, 1985·Epilepsia·M J DaltonJ A Messenheimer
Jan 1, 1984·European Journal of Clinical Pharmacology·L K WebsterF J Vajda
Jul 13, 1984·The American Journal of Medicine·J S Goodwin
Oct 1, 1983·Acta Neurologica Scandinavica·J SonneP B Andreasen
Jan 1, 1983·Clinical Pharmacology and Therapeutics·T TomsonL Bertilsson
Apr 1, 1981·Annals of Internal Medicine·N Telerman-ToppetC Cöers

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Citations

Nov 1, 1994·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C IñiguezA Jimenez-Escrig
Jul 1, 1996·The Journal of Emergency Medicine·J F Naradzay, J S Olshaker
Aug 15, 1989·Biochemical and Biophysical Research Communications·M LevineG D Bellward
Aug 1, 1989·Surgical Neurology·K S OlesJ K Penry
Jan 1, 1997·Journal of the American Academy of Dermatology·D J Fader, T M Johnson
Nov 1, 1994·The Annals of Pharmacotherapy·B D Patterson
Jan 1, 1990·The Journal of International Medical Research·F PisaniR Di Perri
Mar 1, 1994·The Annals of Pharmacotherapy·E R Gonzalez, J A Grillo

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