PMID: 6676919Oct 1, 1983

Cimetidine and parietal cell regeneration in experimental wounds in rat gastric mucosa. A light and electron microscopic study

Scandinavian Journal of Gastroenterology
H Blom

Abstract

Cimetidine, 75 mg/kg body weight, was given twice daily by gastric tube to rats with experimental gastric ulcers. After 130 days' treatment the rats were killed, and sections from the wounds and normal mucosa were prepared for light and electron microscopy. Light microscopic studies showed that the regenerating mucosa in the wounds was thicker in the cimetidine-treated animals than in the controls. Stereological analyses demonstrated no differences in mean size of the parietal cells or in parietal cell volume density between the cimetidine-treated and the untreated groups, but an increase in the secretory surface density was detected in the parietal cells from rats that had been given cimetidine.

References

Dec 1, 1979·AJR. American Journal of Roentgenology·E R Weibel
Jun 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·J F Rehfeld, F Stadil

Citations

Jan 1, 1990·Cytotechnology·J H ResauK A Elliget
Nov 1, 1995·Digestive Diseases and Sciences·F HalterA Tarnawski
Jul 5, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Susumu Okabe, Kikuko Amagase
Oct 1, 1995·Scandinavian Journal of Gastroenterology·K KuboY Kohgo
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·H Blom
Jul 1, 1988·Baillière's Clinical Gastroenterology·K G Wormsley
Sep 1, 1984·Acta Pathologica Japonica·T ShimodaM Ikegami
Jan 1, 1991·Alimentary Pharmacology & Therapeutics·A TarnawskiW J Krause
Jan 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·H BeckL A Christiansen
Dec 1, 1986·Drug Intelligence & Clinical Pharmacy·S MohamedV A Hanson

Related Concepts

Tagamet
Structure of Pyloric Gland
Gastrin
Parietal Cells, Gastric
August Rats
Natural Regeneration
Gastric Ulcer
Wound Healing

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