PMID: 6107157Sep 20, 1980Paper

Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism

British Medical Journal
D A HenryM J Langman

Abstract

Paired studies of hepatic microsomal function were conducted in eight subjects during treatment with two histamine H2 antagonists, cimetidine and ranitidine. Cimetidine but not ranitidine inhibited the metabolism of antipyrine (phenazone) and demethylation of aminopyrine (aminophenazone) as measured by breath 14CO2 production after intravenous injection of 14C-aminopyrine. These results suggest that the metabolic inhibitory actions on the liver may be separated from H2 antagonist effects, and that ranitidine has an advantage over cimetidine by not inhibiting microsomal drug oxidative function.

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Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·K W SomervilleM J Langman
Jan 1, 1983·European Journal of Clinical Pharmacology·M DøssingH E Poulsen
Jan 1, 1983·European Journal of Clinical Pharmacology·H G GrigoleitP U Witte
Jan 1, 1985·European Journal of Clinical Pharmacology·H P HoenschE E Ohnhaus
Jan 1, 1983·European Journal of Clinical Pharmacology·U KlotzE E Ohnhaus
Sep 1, 1985·Canadian Anaesthetists' Society Journal·J G Stock, A D Sutherland
May 1, 1983·Canadian Anaesthetists' Society Journal·J G Williams
Apr 1, 1985·European Journal of Drug Metabolism and Pharmacokinetics·P MojaverianR K Ferguson
Jan 1, 1992·European Journal of Drug Metabolism and Pharmacokinetics·H MönigH M Schulte
Jun 1, 1983·Immunopharmacology·J DescotesJ C Evreux
Jan 1, 1985·Pharmacology & Therapeutics·M C GerberJ R Bianchine
Jan 1, 1987·Pharmacology & Therapeutics·M MitchardB M Mullinger
Dec 1, 1986·Toxicology Letters·J F Ghersi-EgeaC Saunier
Mar 1, 1989·The Journal of Pediatrics·J L Sutphen, V L Dillard
Jan 16, 1982·Lancet·J Feeley, E Guy
Mar 13, 1982·Lancet
Apr 17, 1982·Lancet·E G Black, R Hoffenberg
Apr 17, 1982·Lancet·D Jack, D A Richards
Apr 17, 1982·Lancet·T H KokD W Holt
Mar 19, 1981·The New England Journal of Medicine·J FeelyA J Wood
Jan 7, 1982·The New England Journal of Medicine·M DanilewitzB Hirschowitz
Sep 12, 1981·British Medical Journal·M GuslandiA Tittobello
May 1, 1982·British Medical Journal·A M HeagertyL Patel
Jun 25, 1983·British Medical Journal·D JackR N Smith
Feb 1, 1983·Postgraduate Medical Journal·F I LeeF T Costello
Jan 1, 1989·European Journal of Clinical Pharmacology·N H BrockmeyerE E Ohnhaus
Jun 11, 2011·Drug Discovery Today·Fabrizio GiordanettoChristian Tyrchan
Jan 1, 1984·Current Problems in Surgery·B E Stabile, E Passaro
Sep 1, 1983·Cancer Letters·R BossaI Galatulas
Mar 1, 1987·British Journal of Clinical Pharmacology·S R SmithM R Wilkins
Jul 1, 1987·British Journal of Clinical Pharmacology·G I Adebayo, A F Mabadeje
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H K SeitzB Kommerell
Feb 1, 1985·British Journal of Clinical Pharmacology·J G KellyD G McDevitt
Apr 1, 1983·British Journal of Clinical Pharmacology·R W WattsD J Shearman
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G W MihalyF J Vajda

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