Cimetidine does not prevent lung injury in newborn premature infants.

Pediatric Research
Robert B CottonSteven Steele

Abstract

Animal studies have shown that induction of cytochrome P450 (CYP) in the lung by oxygen exposure may result in the release of free radical oxidants and arachidonic acid metabolites, which can cause lung injury that is reduced by treatment with cimetidine, a CYP inhibitor. To determine whether cimetidine would reduce lung injury in human infants at risk for chronic lung disease, we conducted a randomized clinical trial in which we administered either cimetidine or a placebo for 10 d beginning < 24 h after birth to 84 newborn infants weighing < or = 1250 g who were receiving O2 and mechanical ventilation. Cimetidine had no significant effect on severity of respiratory insufficiency assessed at 10 d postnatal age. F2-isoprostane levels (a marker of oxidant injury) in tracheal aspirates were significantly higher in the cimetidine group at 4 d and at 10 d. There were no significant differences between the groups in tracheal aspirate levels of inflammatory markers (leukotriene B4, IL-8, and nucleated cell count) or arachidonic acid metabolites. We conclude that cimetidine does not reduce lung injury in newborn premature infants receiving O2 and mechanical ventilation. It is possible that cimetidine was not an adequate CYP inhibitor i...Continue Reading

References

May 1, 1978·The Journal of Surgical Research·J R LillyN B Javitt
Jun 30, 1992·Biochemical and Biophysical Research Communications·H SakaiY Kikkawa
Aug 1, 1992·American Journal of Respiratory Cell and Molecular Biology·N W ToddA R Whorton
Nov 1, 1990·The Journal of Clinical Investigation·G K BysaniJ R Hoidal
Dec 1, 1989·Journal of Applied Physiology·T A HazinskiT N Hansen
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J C GonderJ A Will
Mar 1, 1985·Drug Intelligence & Clinical Pharmacy·C W LloydB D Taylor
Dec 1, 1983·American Journal of Diseases of Children·J V ArandaJ J Schentag
Jan 1, 1984·Developmental Pharmacology and Therapeutics·J A ZiemniakJ J Schentag
Oct 1, 1995·The Journal of Clinical Investigation·T A HazinskiA DeMatteo
May 1, 1995·The Journal of Clinical Investigation·D C ZeldinJ H Capdevila
Oct 27, 1999·Biomedical Chromatography : BMC·K XuI A Blair
Jul 14, 2001·The Journal of Biological Chemistry·D C Zeldin
Jul 17, 2001·Biochemical and Biophysical Research Communications·J H Capdevila, J R Falck
Jun 5, 2002·Current Opinion in Lipidology·Deanna L Kroetz, Darryl C Zeldin
Oct 22, 2002·Lancet·Daniel W Nebert, David W Russell
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·David J GranvilleRoberta A Gottlieb
Jun 17, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anuj SinhaBhagavatula Moorthy
Jul 28, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Mario A RojasAngela Leon

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Citations

Dec 17, 2009·Pediatrics·Catherine A GolskiAnna Maria Hibbs
Apr 24, 2014·Annals of the American Thoracic Society·Cindy T McEvoyJudy L Aschner
Dec 4, 2013·Antioxidants & Redox Signaling·Sara K Berkelhamer, Kathryn N Farrow
Jun 5, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Krithika LingappanBhagavatula Moorthy
Sep 4, 2008·Expert Opinion on Emerging Drugs·Anne Greenough
Sep 9, 2009·Seminars in Fetal & Neonatal Medicine·Matthew M LaughonCarl Bose
Oct 1, 2008·Toxicology and Applied Pharmacology·Kushal Y BhaktaBhagavatula Moorthy
Feb 15, 2015·Free Radical Biology & Medicine·Lihua WangBhagavatula Moorthy
Aug 6, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michael T YarboroJeff Reese

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