PMID: 589306Dec 10, 1977

Cimetidine for duodenal ulceration in patients undergoing haemodialysis

British Medical Journal
C C DohertyM G McGeown

Abstract

Peptic ulcer is a common problem in advanced renal failure, but most drugs for ulcers are hazardous in this condition. In a small open study cimetidine was given to nine patients with acid hypersecretion and endoscopically diagnosed duodenal ulceration who were undergoing haemodialysis. The patients obtained good pain relief and suffered no serious side effects. Both basal and stimulated acid output fell considerably and the plasma gastrin response to food increased during treatment. Two patients with recurrent vomiting during haemodialysis had a striking response to cimetidine, which suggested that such vomiting may be acid-mediated in some patients. These preliminary results suggest that cimetidine may prove to be an advance in the management of peptic ulcer in uraemic patients.

References

May 14, 1977·Lancet·C C Doherty, M G McGeown
Mar 27, 1976·Lancet·M J Langman, A R Cooke
Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Oct 9, 1971·Lancet·E J HadjiyannakisR Y Calne
Jun 18, 1970·The New England Journal of Medicine·R F Barreras

Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·T TakabatakeN Hashimoto
Apr 17, 1979·European Journal of Clinical Pharmacology·R LarssonB Norlander
Jan 1, 1982·European Journal of Clinical Pharmacology·R LarssonL Strouth
Jan 1, 1988·European Journal of Clinical Pharmacology·J H LinG A Hessey
May 3, 1979·The New England Journal of Medicine·D H Van ThielG Paul
Mar 10, 1979·British Medical Journal·R H JonesV Parsons
Aug 1, 1985·Anaesthesia and Intensive Care·K Hillman

Related Concepts

Tagamet
Duodenal Ulcer
Gastric Acidity Determination
Gastrin
Guanidines
Hemodialysis
Kidney Failure, Chronic
Vomiting

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