Cimetidine in acute gastric mucosal bleeding: results of a double-blind randomized trial

Digestive Diseases and Sciences
J TerésJ Rodes

Abstract

The hemostatic effect of cimetidine has been investigated in a double-blind, randomized trial in patients bleeding from acute mucosal lesions. During a 48-hr period, hemostasis was achieved in 5 of 15 patients (33%) treated with intravenous cimetidine administered with antacid therapy and in four of 12 patients (33%) treated with antacids alone. In a second stage of the trial, the effect of oral cimetidine in preventing further bleeding was investigated. Bleeding did not recur in 18 patients receiving cimetidine and antacids while 6 out of 20 patients who were given antacids alone suffered further hemorrhage during the 14-day period of the study. It is concluded that intravenous cimetidine administered with antacids was not found more effective in obtaining hemostasis than antacids alone. When given orally to patients who had been bleeding from acute lesions but were not doing so at the beginning of treatment, cimetidine with antacids is more effective than antacids alone in the prevention of further bleeding.

References

Dec 1, 1976·The Surgical Clinics of North America·F G Moody, L Y Cheung
Jun 5, 1975·The New England Journal of Medicine·M J WelchL A Sherman
Jan 1, 1972·Annual Review of Medicine·R Menguy

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Citations

Mar 1, 1981·World Journal of Surgery·L Y Cheung
Nov 15, 1980·British Medical Journal·D Hetzel
Nov 15, 1980·British Medical Journal·K L WoodsJ M Morrison
Jul 1, 1982·Pharmacotherapy·A H Spiro, M A Peppercorn
May 1, 1982·Postgraduate Medicine·J B Marshall

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