PMID: 6990675Jan 1, 1980

Cimetidine in the prevention of acid aspiration during anesthesia

Acta Anaesthesiologica Scandinavica
P KirkegaardP Kirkegaard

Abstract

In a controlled, randomized, double-blind trial, the value of cimetidine as prophylaxis against acid aspiration pneumonitis was studied. Compared to placebo, cimetidine reduced the volume as well as the acidity of the gastric contents significantly. The patients at risk of developing severe pneumonitis after aspiration (pH less than 2.5 and volume greater than 20 ml) were reduced from 55% in the placebo group to 0 in the group having received cimetidine 400 mg the night before and a further 400 mg on the morning of surgery. Premedication with cimetidine may be useful if rapid intubation cannot be anticipated.

References

Dec 1, 1975·British Journal of Clinical Pharmacology·W L BurlandJ H Wyllie
Dec 1, 1978·British Journal of Anaesthesia·P J KeatingD W Watson
Aug 21, 1975·The New England Journal of Medicine·R M HennR A Sturdevant
Dec 1, 1975·Anesthesiology·R W VaughanL Wise
Nov 1, 1974·Anesthesia and Analgesia·R B Roberts, M A Shirley
Jul 1, 1969·Annals of Surgery·L J GreenfieldJ J Coalson
Nov 25, 1965·The New England Journal of Medicine·L D Vandam
Mar 1, 1962·Anesthesiology·W K BANNISTER, A J SATTILARO
Aug 1, 1946·American Journal of Obstetrics and Gynecology·C L MENDELSON

Citations

Sep 1, 1982·Klinische Wochenschrift·G FeifelH Eissner
Jan 1, 1984·Canadian Anaesthetists' Society Journal·A M Lam, J L Clement
May 1, 1983·Canadian Anaesthetists' Society Journal·J G Williams
Sep 17, 1981·The New England Journal of Medicine
Aug 1, 1983·Acta Anaesthesiologica Scandinavica·M TrybaM Zenz
Oct 1, 1982·Acta Anaesthesiologica Scandinavica·G L Olsson, B Hallén
Apr 1, 1996·Food Additives and Contaminants·M MüllerH Illing-Günther
May 1, 1984·Drug Intelligence & Clinical Pharmacy·S F Kowalsky

Related Concepts

General Anesthesia
Insufflation Anesthesia
Tagamet
Clinical Trials
Double-Blind Method
Gastric Juice
Guanidines
Hydrogen-Ion Concentration
Placebos
Aspiration Pneumonia

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