PMID: 42421Oct 1, 1979

Cimetidine in the prevention of the pulmonary acid aspiration (Mendelson's) syndrome

British Journal of Anaesthesia
G DobbJ G Williams

Abstract

Cimetidine 200 mg was given i.v. 1 h before induction of anaesthesia to 20 patients about to undergo emergency surgery. There was an increase in pH of gastric aspirate in all patients (P less than 0.001) and in 80% pH was greater than 2.5 units at the time of induction of anaesthesia. The pH of gastric aspirate continued to increase after induction of anaesthesia and was greater than 4 units in all patients at the time of tracheal extubation and in the early recovery period.

References

Sep 1, 1982·Klinische Wochenschrift·G FeifelH Eissner
Mar 1, 1986·Canadian Anaesthetists' Society Journal·A J Cunningham, P Barry
May 1, 1983·Canadian Anaesthetists' Society Journal·J G Williams
Jan 1, 1984·Pharmacology & Therapeutics·R E Pounder
Mar 29, 1980·Lancet·A Gilston
Sep 17, 1981·The New England Journal of Medicine
May 1, 1982·Anaesthesia and Intensive Care·J WrobelJ M Saunders
Jan 1, 1996·The Journal of International Medical Research·H Tanioka, K Kaga
May 1, 1983·Anaesthesia and Intensive Care·J G Brock-UtneJ Gjessing
May 1, 1984·Drug Intelligence & Clinical Pharmacy·S F Kowalsky

Related Concepts

Gastric Juice
Tagamet
Teens
Gastroesophageal Reflux Disease
General Anesthesia
Respiration
Inspiration Function
Guanidines
Hydrogen-Ion Concentration
Operative Surgical Procedures

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