PMID: 7010874Aug 1, 1980Paper

Cimetidine in the prophylaxis of migraine

Acta Neurologica Scandinavica
R N NandaD G Lambie

Abstract

The prophylactic effect of the histamine H2-blocker cimetidine, either alone or combined with an H1-blocker (chlorpheniramine), was investigated in 34 migraine patients in a double-blind crossover trial. Twelve patients withdrew during the course of the trial, one because of the side effects and the remainder because of failure to attend checkups or to keep adequate record of attacks. In the 22 patients who completed the trial, there were no significant responses to cimetidine or cimetidine + chlorpheniramine, during 3 months' therapy, as compared with 3 months' therapy with placebo, either on number, duration or severity of attacks. The study demonstrates that cimetidine is unlikely to be effective in migraine, and casts doubt on the role of histamine in the development of migraine attacks.

References

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Citations

Jul 1, 1990·Journal of Ethnopharmacology·T Mustafa, K C Srivastava
Sep 3, 2009·Nature Reviews. Neurology·Wandana Nanhoe-MahabierBastiaan R Bloem
Jan 1, 1990·Child: Care, Health and Development·J Zur, W Yule
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May 15, 2013·Cephalalgia : an International Journal of Headache·Messoud AshinaJes Olesen
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Mar 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·David TaylorUNKNOWN pharmacology subgroup of the National Institute for Health and Clinical Excellence Guideline Development Group for Depressi
Apr 17, 2003·Neonatal Network : NN·Susan Givens Bell
Sep 29, 2011·CNS Neuroscience & Therapeutics·Todd A SmithermanDonald B Penzien
Mar 27, 2019·The Journal of Headache and Pain·Jacob WormJes Olesen

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